Skip to main content

Advertisement

SpringerLink
Log in

Effect of photobiomodulation therapy on regenerative endodontic procedures: a scoping review

  • Review Article
  • Published:
Lasers in Dental Science Aims and scope Submit manuscript

Abstract

Purpose

The loss of dental pulp vitality and the subsequent need for conventional endodontic treatment have caused undesirable clinical outcomes, which become even more critical when dealing with immature permanent teeth. Photobiomodulation therapy could overcome these impairments by improving the environmental conditions, once it can compensate oxidative stress and increase blood supply to implanted stem cells, improving their survival rate and preventing their premature death. This study aimed to conduct a scoping review to evaluate if photobiomodulation therapy is able to influence the outcome of regenerative endodontic procedures.

Methods

Relevant articles were searched and obtained from library sources and the following online databases: MEDLINE/PubMed database, SciVerseScopusTM (SS), and ISI Web of a ScienceTM up to November 2018.

Results

From 96 potentially relevant studies initially identified, 6 papers fulfilled the eligibility criteria and were considered for this review. These were in vitro (n = 4) and in vivo studies (n = 2) that applied wavelengths of 810 nm (n = 3) or 660 nm (n = 3), all in continuous wave. The energy densities applied were mostly between 2 and 5 J/cm2. Five out of the six studies showed that photobiomodulation therapy led to greater stem cell differentiation rates in vitro and improved pulp-like tissue regeneration in vivo, increasing tertiary dentin volumes and also improving pulp-like tissue formation. The studies showed that photobiomodulation therapy led to greater stem cell differentiation rates in vitro and improved pulp-like tissue regeneration in vivo, increasing tertiary dentin volumes and also improving pulp-like tissue formation.

Conclusion

This scoping review showed that photobiomodulation therapy is able to influence positively the outcome of regenerative endodontic procedures. However, due to the small number of studies evaluated here, a secondary evaluatıon should be held forward as a continuation of this scoping review in order to warrant a safe and effective future use in humans.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Hargreaves KM, Diogenes A, Teixeira FB (2013) Treatment options: biological basis of regenerative endodontic procedures. J Endod 39:30–43

    Article  Google Scholar 

  2. Marques MM, Diniz IM, de Cara SP et al (2016) Photobiomodulation of dental derived mesenchymal stem cells: a systematic review. Photomed Laser Surg 34:500–508

    Article  Google Scholar 

  3. Wang X, Thibodeau B, Trope M, Lin LM, Huang GT (2010) Histologic characterization of regenerated tissues in canal space after the revitalization/revascularization procedure of immature dog teeth with apical periodontitis. J Endod 36:56–63

    Article  Google Scholar 

  4. Shimizu E, Jong G, Partridge N, Rosenberg PA, Lin LM (2012) Histologic observation of a human immature permanent tooth with irreversible pulpitis after revascularization/regeneration procedure. J Endod 38:1293–1297

    Article  Google Scholar 

  5. He L, Zhong J, Gong Q et al (2017) Treatment of necrotic teeth by apical revascularization: meta-analysis. Sci Rep 7:13941

    Article  Google Scholar 

  6. Diogenes A, Ruparel NB (2017) Regenerative endodontic procedures: clinical outcomes. Dent Clin N Am 61:111–125

    Article  Google Scholar 

  7. Thibodeau B, Teixeira F, Yamauchi M, Caplan DJ, Trope M (2007) Pulp revascularization of immature dog teeth with apical periodontitis. J Endod 33:680–689

    Article  Google Scholar 

  8. Torabinejad M, Nosrat A, Verma P, Udochukwu O (2017) Regenerative endodontic treatment or mineral trioxide aggregate apical plug in teeth with necrotic pulps and open apices: a systematic review and meta-analysis. J Endod 43:1806–1820

    Article  Google Scholar 

  9. Tong HJ, Rajan S, Bhujel N, Kang J, Duggal M, Nazzal H (2017) Regenerative endodontic therapy in the management of nonvital immature permanent teeth: a systematic review-outcome evaluation and meta-analysis. J Endod 43:1453–1464

    Article  Google Scholar 

  10. Kahler B, Rossi-Fedele G, Chugal N, Lin LM (2017) An evidence-based review of the efficacy of treatment approaches for immature permanent teeth with pulp necrosis. J Endod 43:1052–1057

    Article  Google Scholar 

  11. Lei L, Chen Y, Zhou R, Huang X, Cai Z (2015) Histologic and immunohistochemical findings of a human immature permanent tooth with apical periodontitis after regenerative endodontic treatment. J Endod 41:1172–1179

    Article  Google Scholar 

  12. Peng C, Zhao Y, Wang W, Yang Y, Qin M, Ge L (2017) Histologic findings of a human immature revascularized/regenerated tooth with symptomatic irreversible pulpitis. J Endod 43:905–909

    Article  Google Scholar 

  13. Lovelace TW, Henry MA, Hargreaves KM, Diogenes A (2011) Evaluation of the delivery of mesenchymal stem cells into the root canal space of necrotic immature teeth after clinical regenerative endodontic procedure. J Endod 37:133–138

    Article  Google Scholar 

  14. Marques MM, de Cara SP, Abe GL, Pedroni AC, Diniz IM, Moreira MS (2017) Effects of photobiomodulation therapy in dentoalveolar-derived mesenchymal stem cells: a review of literature. Lasers Dent Sci 1:1–7

    Article  Google Scholar 

  15. Xinaris C, Morigi M, Benedetti V et al (2013) A novel strategy to enhance mesenchymal stem cell migration capacity and promote tissue repair in an injury specific fashion. Cell Transplant 22:423–436

    Article  Google Scholar 

  16. Eduardo FP, Bueno DF, de Freitas PM et al (2008) Stem cell proliferation under low intensity laser irradiation: a preliminary study. Lasers Surg Med 40:433–438

    Article  Google Scholar 

  17. Diniz IMA, Carreira ACO, Sipert CR et al (2018) Photobiomodulation of mesenchymal stem cells encapsulated in an injectable rhBMP4-loaded hydrogel directs hard tissue bioengineering. J Cell Physiol 233:4907–4918

    Article  Google Scholar 

  18. Anders JJ, Lanzafame RJ, Arany PR (2015) Low-level light/laser therapy versus photobiomodulation therapy. Photomed Laser Surg 33:183–184

    Article  Google Scholar 

  19. American Association of Endodontists (2017) Scope of endodontics: regenerative endodontic. AAE, Chicago https://www.aae.org. Accessed November 2018

    Google Scholar 

  20. Arksey H, O’Malley L (2005) Scoping studies: towards a methodological framework. J Soc Res Methodol 8:19–32

    Article  Google Scholar 

  21. Fekrazad R, Seraj B, Ghadimi S, Tamiz P, Mottahary P, Dehghan MM (2015) The effect of low-level laser therapy (810 nm) on root development of immature permanent teeth in dogs. Lasers Med Sci 30:1251–1257

    Article  Google Scholar 

  22. Moreira MS, Diniz IM, Rodrigues MF et al (2017) In vivo experimental model of orthotopic dental pulp regeneration under the influence of photobiomodulation therapy. J Photochem Photobiol B 166:180–186

    Article  Google Scholar 

  23. Pereira LO, Longo JP, Azevedo RB (2012) Laser irradiation did not increase the proliferation or the differentiation of stem cells from normal and inflamed dental pulp. Arch Oral Biol 57:1079–1085

    Article  Google Scholar 

  24. Arany PR, Cho A, Hunt TD et al (2014) Photoactivation of endogenous latent transforming growth factor-β1 directs dental stem cell differentiation for regeneration. Sci Transl Med 6:238ra69

    Article  Google Scholar 

  25. Theocharidou A, Bakopoulou A, Kontonasaki E et al (2017) Odontogenic differentiation and biomineralization potential of dental pulp stem cells inside Mg-based bioceramic scaffolds under low-level laser treatment. Lasers Med Sci 32:201–210

    Article  Google Scholar 

  26. Ferreira LS, Diniz IMA, Maranduba CMS et al (2018) Short-term evaluation of photobiomodulation therapy on the proliferation and undifferentiated status of dental pulp stem cells. Lasers Med Sci. https://doi.org/10.1007/s10103-018-2637-z

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. AALZ Lasers in Dentistry, RWTH Aachen University Hospital, Aachen, Germany

    Alshaimaa Mohammed Alnagar, Mohamed Mahmoud, Norbert Gutknecht & Marcia Martins Marques

  2. Department of Conservative Dentistry, Periodontology and Preventive Dentistry, RWTH Aachen University Hospital, Aachen, Germany

    Norbert Gutknecht

  3. Post Graduation Program, School of Dentistry, Ibirapuera University (UNIB), Av. Interlagos, 1329 - 4° - Chácara Flora, São Paulo, SP, 04661-100, Brazil

    Maria Stella Moreira & Marcia Martins Marques

  4. Department of Restorative Dentistry and Endodontics, School of Dentistry, University of São Paulo (USP), São Paulo, SP, Brazil

    Giovanna Sarra & Giovanna Lopes Carvalho

Authors
  1. Alshaimaa Mohammed Alnagar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mohamed Mahmoud
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Norbert Gutknecht
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Maria Stella Moreira
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Giovanna Sarra
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Giovanna Lopes Carvalho
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Marcia Martins Marques
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marcia Martins Marques.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Alnagar, A.M., Mahmoud, M., Gutknecht, N. et al. Effect of photobiomodulation therapy on regenerative endodontic procedures: a scoping review. Laser Dent Sci 3, 227–234 (2019). https://doi.org/10.1007/s41547-019-00076-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s41547-019-00076-5

Keywords

Search

Navigation