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Comparison of fibroblast inhibitory effect of α-tocopherol succinate and 13-cis retinol

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Annals of Ophthalmology

Abstract

The effects of vitamins E and A derivatives on proliferation and migration of fibroblasts in cell culture were compared. In vitro wound repair was determined. Treatment was divided by group: 0.1% ethanol (group 1), α-tocopherol succinate (50 μM) dissolved in ethanol (final concentration 0.1%; group 2), and 13-cis retinol (10 μM; group 3). There were no differences among the groups within the first 24 hours. At 48 hours, α-tocopherol succinate demonstrated inhibitory effects on wound repair.

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Authors and Affiliations

  1. Department of Optthalmology Miguel Servet Hospital, University of Zaragoza, C/General Capaz 17, c-6 1°B, 50012, Zaragoza, Spain

    I. Pinilla MD, J. M. Larrosa MD, V. Polo MD & F.M. Honrubia MD

  2. Investigation Unit, University of Zaragoza, Zaragoza, Spain

    E. Piazuelo MD & P. Jimenez MD

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  1. I. Pinilla MD
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  2. J. M. Larrosa MD
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  3. V. Polo MD
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  6. F.M. Honrubia MD
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Pinilla, I., Larrosa, J.M., Polo, V. et al. Comparison of fibroblast inhibitory effect of α-tocopherol succinate and 13-cis retinol. Ann Ophthalmol 34, 108–112 (2002). https://doi.org/10.1007/s12009-002-0037-1

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  • DOI: https://doi.org/10.1007/s12009-002-0037-1

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