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Performance profile of a FDG-PET cancer screening program for detecting gastric cancer: results from a nationwide Japanese survey

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Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

It has been reported that gastric cancer is the sixth most common cancer found during the 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) cancer screening program, which is defined as cancer screening of asymptomatic subjects using FDG-PET(/CT) (in combination with other screening tests or not). The aim of this study was to analyze the detection rate and the effectiveness of the FDG-PET cancer screening program at detecting gastric cancer between 2006 and 2009 in Japan.

Materials and methods

A total of 153,775 asymptomatic subjects (92,255 men, 61,520 women) between 30 and 80 years old underwent the FDG-PET cancer screening program. Of these, we analyzed 790 cases with findings of possible gastric cancer in any screening test.

Results

The number of cases who were verified to have gastric cancer was 124. Among these, only 47 cases were detected by FDG-PET, which resulted in a relative sensitivity of 37.9 % and a positive predictive value of 33.6 %. The relative sensitivity of FDG-PET was much lower than those of gastric endoscopy and the serum pepsinogen test.

Conclusion

The FDG-PET screening program in Japan detected some cases of early-stage gastric cancer, but this was not achieved using FDG-PET alone but in combination with gastric endoscopy. Gastric endoscopy should be included in FDG-PET cancer screening programs to screen for gastric cancer.

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Acknowledgments

This work was supported by the National Cancer Center Research and Development Fund 23-A-25, Radiopharmaceuticals and Labeled Compounds Radiopharmaceutical and Radioisotope Supply Business Promotion Department, Japan Radioisotope Association, Sachiko Yanagida and Yoshihide Nakamura.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjyuku-ku, Tokyo, 162-8655, Japan

    Ryogo Minamimoto

  2. Division of Molecular Imaging, Institute of Biomedical Research and Innovation, Kobe, Japan

    Michio Senda

  3. Atsuchi Memorial Institute of Radiology, Atsuchi Memorial Clinic PET Center, Kagoshima, Japan

    Seishi Jinnouchi

  4. Division of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan

    Takashi Terauchi

  5. Department of Radiology, Koga Hospital 21 PET Center, Kurume, Japan

    Tsuyoshi Yoshida

  6. Department of Radiology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan

    Ryogo Minamimoto & Tomio Inoue

Authors
  1. Ryogo Minamimoto
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  2. Michio Senda
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  3. Seishi Jinnouchi
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  4. Takashi Terauchi
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  5. Tsuyoshi Yoshida
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  6. Tomio Inoue
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Corresponding author

Correspondence to Ryogo Minamimoto.

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Minamimoto, R., Senda, M., Jinnouchi, S. et al. Performance profile of a FDG-PET cancer screening program for detecting gastric cancer: results from a nationwide Japanese survey. Jpn J Radiol 32, 253–259 (2014). https://doi.org/10.1007/s11604-014-0294-0

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  • DOI: https://doi.org/10.1007/s11604-014-0294-0

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