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Reinereins A and B, new onocerane triterpenoids from Reinwardtiodendron cinereum

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Abstract

Bioactivity guided separation of Reinwardtiodendron cinereum barks methanol extract led to the isolation of two new onocerane triterpenoids, reinereins A and B (1 and 2), together with three known onocerane triterpenoids. Their structures were elucidated on the basis of NMR spectroscopic data. In vitro cytotoxic activities of the isolated compounds against several type of cancer cells were evaluated.

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Acknowledgements

This work was supported by Grants in-Aid for Scientific Research from JSPS, Japan.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan

    Alfarius Eko Nugroho, Daisuke Inoue, Chin Piow Wong, Yusuke Hirasawa, Toshio Kaneda & Hiroshi Morita

  2. Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa, 769-2193, Japan

    Osamu Shirota

  3. Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia

    A. Hamid A. Hadi

Authors
  1. Alfarius Eko Nugroho
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  2. Daisuke Inoue
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  3. Chin Piow Wong
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  4. Yusuke Hirasawa
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  5. Toshio Kaneda
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  7. A. Hamid A. Hadi
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  8. Hiroshi Morita
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Correspondence to Hiroshi Morita.

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Nugroho, A.E., Inoue, D., Wong, C.P. et al. Reinereins A and B, new onocerane triterpenoids from Reinwardtiodendron cinereum. J Nat Med 72, 588–592 (2018). https://doi.org/10.1007/s11418-018-1188-8

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  • DOI: https://doi.org/10.1007/s11418-018-1188-8

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