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Periodic monitoring of persistent organic pollutants and molecular damage in Cyprinus carpio from Büyük Menderes River

  • Persistent Organic Pollutants (POPs): a global issue, a global challenge
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Abstract

Concentrations of persistent organic pollutants (POPs) were quantified in river water and sediment, as well as in the liver and muscle tissues of Cyprinus carpio that were sampled four times in a year at three stations in the Büyük Menderes River (BMR). Potential biomarkers of possible cellular molecular damage, namely lipid peroxidation (LPO) degradation products, protein carbonyls (PCO) and DNA repair product 8-hydroxy-2′-deoxyguanosine (8-OHdG), were analysed. All the targeted pollutants were measurable both in biotic and abiotic samples. Interestingly, the results suggested that there was recent organochlorine pesticide (OCP) input into the river water in the first two sampling periods in all stations in contrast to prohibition, while input of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) was not detected. Liver POP concentrations were higher than in muscle, as expected, and were found to decrease from the first to the fourth sampling period in all stations, except PBDEs. Levels of LPO degradation products in the liver and in muscle tissues decreased from the first to the fourth sampling period. This suggests that these markers reflect the lipid damage in respective tissues due to the tissue burden of targeted POPs. Protein carbonyls were the highest in the first sampling period, followed by a dramatic decrease in the second, and then a gradual increase towards the fourth sampling period in all stations. 8-OHdG levels were lower in Sarayköy station in the first sampling period. Among the measured biomarkers, only several LPO degradation products were significantly correlated with OCPs and PCBs in liver tissue.

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Acknowledgments

This study was supported by a grant from The Scientific and Technical Research Council of Turkey (TÜBİTAK) by the grant number 108Y049, and partially by Ebiltem 09BİL002 and by the Ege University Faculty of Pharmacy BAP of 09ECZ013, 09ECZ017 and 11ECZ004. The FABAL facility of Faculty of Pharmacy was utilised in various sample preparation procedures and analyses.

Conflict of interest

None of the authors has a conflict of interest related to this study.

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Author notes

  1. Beste Çağdaş

    Present address: Bioengineering Department, Faculty of Engineering, Kirikkale University, 71450, Merkez-Kirikkale, Turkey

Authors and Affiliations

  1. Department of Toxicology, Faculty of Pharmacy, Ege University, 35100, Bornova-İzmir, Turkey

    Beste Çağdaş, Rasih Kocagöz, İlgen Onat & Hilmi Orhan

  2. Department of Aquaculture, Faculty of Fisheries, Ege University, 35100, Bornova-İzmir, Turkey

    Fatih Perçin

  3. Department of Hydrobiology, Faculty of Fisheries, Ege University, 35100, Bornova-İzmir, Turkey

    Okan Özaydın

Authors
  1. Beste Çağdaş
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  2. Rasih Kocagöz
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  3. İlgen Onat
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  4. Fatih Perçin
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  5. Okan Özaydın
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  6. Hilmi Orhan
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Corresponding author

Correspondence to Hilmi Orhan.

Additional information

Responsible editor: Hongwen Sun

Beste Çağdaş and Rasih Kocagöz contributed equally to this work.

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Çağdaş, B., Kocagöz, R., Onat, İ. et al. Periodic monitoring of persistent organic pollutants and molecular damage in Cyprinus carpio from Büyük Menderes River. Environ Sci Pollut Res 24, 4241–4251 (2017). https://doi.org/10.1007/s11356-015-4848-1

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  • DOI: https://doi.org/10.1007/s11356-015-4848-1

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