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Plant extracts and their components as potential control agents against human head lice

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Abstract

The head lice, Pediculus humanus capitis (Phthiraptera:Pediculidae), is an obligate ectoparasite of humans that causes pediculosis capitis, a nuisance for millions of people worldwide, with high prevalence in children. Pediculosis capitis has been treated by methods that include the physical remotion of lice, various domestic treatments and conventional insecticides. None of these methods render complete protection, and there is clear evidence for the evolution of resistance and cross-resistance to conventional insecticides. Non-toxic alternative options are hence needed for head lice treatment and/or prevention, and natural products from plants, especially essential oils (EOs), are good candidates for safer control agents that may provide good anti-lice activity and low levels of evolved resistance. A few EOs have been tested as repellents with promissory results, although often in vitro tests and clinical trials produce contradictory results. A handful of fixed extracts and several EOs and their individual components have also been tested as contact pediculicides or fumigants. The studies have focused mainly on plant families characterized for the production of EOs. While many EOs and individual compounds showed pediculicide activity, comparing results is difficult due to the diverse bioassay methodologies. Studies of anti-lice activity of individual EO components provide the basis for preliminary conclusions of structure–activity relationships, although no clear patterns can yet be drawn. We here attempt to provide a concise compilation of the available information on anti-lice activity of plant extracts and plant-derived compounds, which we hope may be of help for future developments in this area.

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Abbreviations

DDT:

Dichloro-diphenyl-trichloroethane

DEET:

N,N-diethyl-m-toluamide

EO(s):

Essential oil(s)

K ow :

Octanol-water partitioning coefficients

LT50 :

Lethal time for killing 50% of population

MW:

Molecular weight,

Pv:

Vapour pressure

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Acknowledgements

We thank the editors for the opportunity to prepare this work, and we also wish to thank financial support by the Program for the Development of Basic Sciences (PEDECIBA, Uruguay), and the Organization for the Prohibition of Chemical Weapons (OPCW).

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  1. Laboratorio de Ecología Química, Facultad de Química, UdelaR, Gral. Flores 2124, Montevideo,, CP 11800, Uruguay

    Carmen Rossini, Lucía Castillo & Andrés González

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  1. Carmen Rossini
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  2. Lucía Castillo
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Correspondence to Carmen Rossini.

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Rossini, C., Castillo, L. & González, A. Plant extracts and their components as potential control agents against human head lice. Phytochem Rev 7, 51–63 (2008). https://doi.org/10.1007/s11101-006-9026-0

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