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A continuous process for solid-state dehydration, amorphization and recrystallization of metoclopramide HCL monohydrate studied by simultaneous DSC-FTIR microspectroscopy

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Abstract

The purpose of this study was to investigate the thermal-induced solid-state characterization of metoclopramide hydrochloride monohydrate (MCP H2O) by using a combination of differential scanning calorimetry (DSC) and Fourier-transform infrared (simultaneous DSC-FTIR) microspectroscopy. The DSC and thermogravimetric (TG) analyses were also carried out. The result indicates that a continuous process of dehydration, amorphization and recrystallization for MCP H2O in the solid state was easily evidenced via the thermal responsive IR spectral changes by using this simultaneous DSC-FTIR microspectroscopy. In the heating course, one mole of water was first dehydrated from the MCP H2O sample beyond 77 °C, was then quickly transformed to an amorphous form due to the appearance of weak broad IR bands, and continuously recrystallized from 148 °C by showing the sharp IR bands. This one-step novel simultaneous DSC-FTIR microspectroscopy might be available for studying the changes in the progressive processes of the thermal-dependent solid-state characterizations of drugs.

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Authors and Affiliations

  1. Department of Applied Chemistry, National ChiaYi University, ChiaYi, Taiwan, Republic of China

    Shun-Li Wang & Yu-Chiau Wong

  2. Department of Biotechnology, Yuanpei University, Yuanpei Street, Hsin Chu, Taiwan, Republic of China

    Wen-Ting Cheng & Shan-Yang Lin

Authors
  1. Shun-Li Wang
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  2. Yu-Chiau Wong
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  3. Wen-Ting Cheng
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  4. Shan-Yang Lin
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Correspondence to Shun-Li Wang or Shan-Yang Lin.

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Wang, SL., Wong, YC., Cheng, WT. et al. A continuous process for solid-state dehydration, amorphization and recrystallization of metoclopramide HCL monohydrate studied by simultaneous DSC-FTIR microspectroscopy. J Therm Anal Calorim 104, 261–264 (2011). https://doi.org/10.1007/s10973-010-0998-z

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  • DOI: https://doi.org/10.1007/s10973-010-0998-z

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