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Association of a vascular endothelial growth factor gene 936 C/T polymorphism with breast cancer risk: a meta-analysis

  • Epidemiology
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Abstract

Published studies on the association between the vascular endothelial growth factor (VEGF) gene 936 C/T polymorphism and breast cancer risk are inconclusive, and a meta-analysis is required to verify the association. Nine studies, including a total of 4,973 cases and 5,035 controls, were subjected to meta-analysis. When all eligible subjects were pooled for meta-analysis, the CT + TT genotypes were not associated with a significant decrease in breast cancer risk (odds ratio = 0.87; 95% confidence interval 0.75–1.02; P = 0.087). We also categorized by ethnicity (Caucasian, Asian, or mixed) for subgroup analysis, however, according to this subgroup analysis, we found no significant association between the CT and TT versus CC genotype with breast cancer risk reduction in any of the subgroups. We conclude that the VEGF gene 936 C/T polymorphism does not affect breast cancer risk.

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Acknowledgments

This study was supported by a grant of the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (0412-CR01-0704-001).

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Authors and Affiliations

  1. Department of Radiation Oncology, Korea University Guro Hospital, 97 Gurodong-Gil Guro-Ku, Seoul, Korea

    Dae Sik Yang

  2. Division of Medical Oncology, Department of Internal Medicine, Korea University Guro Hospital, 97 Gurodong-Gil Guro-Ku, Seoul, Korea

    Kyong Hwa Park, Yeul Hong Kim, Jun Suk Kim & Jae Hong Seo

  3. Department of Diagnostic Radiology, Korea University Guro Hospital, 97 Gurodong-Gil Guro-Ku, Seoul, Korea

    Ok Hee Woo

  4. Department of Surgery, Korea University Guro Hospital, 97 Gurodong-Gil Guro-Ku, Seoul, Korea

    Sang Uk Woo, Eun Sook Lee & Jae-Bok Lee

  5. Department of Pathology, Korea University Guro Hospital, 97 Gurodong-Gil Guro-Ku, Seoul, Korea

    Ae-Ree Kim

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  1. Dae Sik Yang
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  2. Kyong Hwa Park
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  3. Ok Hee Woo
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  10. Jae Hong Seo
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Correspondence to Jae Hong Seo.

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Yang, D.S., Park, K.H., Woo, O.H. et al. Association of a vascular endothelial growth factor gene 936 C/T polymorphism with breast cancer risk: a meta-analysis. Breast Cancer Res Treat 125, 849–853 (2011). https://doi.org/10.1007/s10549-010-1070-1

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  • DOI: https://doi.org/10.1007/s10549-010-1070-1

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