Abstract
We focus on research to develop a compact human blood sampling device used for the Self Monitoring of Blood Glucose (SMBG). The SMBG comprises: (1) an indentation system using a shape memory alloy (SMA) actuator to force a microneedle through the skin; (2) a micro electrical pumping system to extract blood using a bimorph type piezoelectric microactuator; (3) a biosensor using an enzyme such as glucose oxidase (GOx) to detect and evaluate the amount of glucose in extracted blood. A titanium microneedle the same size as a female mosquito's labium (60 μm outer diameter, 25 μm inner diameter) was produced by the sputter deposition method. The mechanical design of the device was based upon the mosquito's blood sampling mechanism. The blood extraction system worked well. We measured the performance of the principal components: the indentation load for a microneedle of external diameter 100 μm was found to be 0.1 N. The pumping system has an extraction speed of about 2 μl/min for whole blood. This is similar to that achieved by the mosquito.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
J.H. Barbee and G.R. Cokelet, Macrovascular Research 3 1, 6–16 (1971).
T. Ikeshoji, Mosquitoes (Tokyo University Press, 1993), in Japanese.
J.C. Jones, Scientific American 238, 112–120 (1978).
H. Kawahara, S. Ochi, K. Tanetani, K. Kato, M. Isogai, Y. Mizuno, H. Yamamoto, and A. Yamagami, Shika Rikogaku Zasshi 4(6), 65–85 (1963).
S. Kurihara, T. Kurita, and S. Katayama, J. New Rem. & Clin. 52(2), 104–112 (2003), in Japanese.
F.J. Martin and C. Grove, Biomedelical Micodevices 3(2), 97–108 (2001).
A. Oki, M. Takai, H. Ogawa, Y. Takamura, T. Fukasawa, J. Kikuchi, Y. Ito, T. Ichiki, and Y. Horiike, Jpn. J. Appl. Phys. 42, 3722–3727 (2003).
Y. Okazaki, Y. Ito, A. Ito, and T. Tateishi, Annual Report of Mechanical Engineering Laboratory 46(5) 397–416 (1992), in Japanese.
Piezo-ceramic, Technical handbook, Fuji Ceramics Corporation.
L.M. Schetky, Scientific American 241–245, 68–76 (1979).
M. Tabib-Azar, Microactuators (Kluwer Academic Publishers, 1998).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Tsuchiya, K., Nakanishi, N., Uetsuji, Y. et al. Development of Blood Extraction System for Health Monitoring System. Biomed Microdevices 7, 347–353 (2005). https://doi.org/10.1007/s10544-005-6077-8
Issue Date:
DOI: https://doi.org/10.1007/s10544-005-6077-8