Abstract
Purpose
The study compares glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging of intervertebral discs corrected for solely B0 inhomogeneities or both B0 and B1 inhomogeneities.
Methods
Lumbar intervertebral discs of 20 volunteers were examined with T2-weighted and gagCEST imaging. Field inhomogeneity correction was performed with B0 correction only and with correction of both B0 and B1. GagCEST effects measured by the asymmetric magnetization transfer ratio (MTRasym) and signal-to-noise ratio (SNR) were compared between both methods.
Results
Significant higher MTRasym and SNR values were obtained in the nucleus pulposus using B0 and B1 correction compared with B0-corrected gagCEST. The GagCEST effect was significantly different in the nucleus pulposus compared with the annulus fibrosus for both methods.
Conclusion
The B0 and B1 field inhomogeneity correction method leads to an improved quality of gagCEST imaging in IVDs compared with only B0 correction.
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References
Ling W, Regatte RR, Navon G, Jerschow A (2008) Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST). Proc Natl Acad Sci U S A 105(7):2266–2270
Saar G, Zhang B, Ling W, Regatte RR, Navon G, Jerschow A (2012) Assessment of glycosaminoglycan concentration changes in the intervertebral disc via chemical exchange saturation transfer. NMR Biomed 25(2):255–261
Roughley PJ, Lee ER (1994) Cartilage proteoglycans: structure and potential functions. Microsc Res Tech 28(5):385–397
Müller-Lutz A, Schleich C, Pentang G, Schmitt B, Lanzman RS, Matuschke F, Wittsack HJ, Miese F (2015) Age-dependency of glycosaminoglycan content in lumbar discs: a 3t gagcEST study. J Magn Reson Imaging 42(6):1517–1523
Haneder S, Apprich SR, Schmitt B, Michaely HJ, Schoenberg SO, Friedrich KM, Trattnig S (2013) Assessment of glycosaminoglycan content in intervertebral discs using chemical exchange saturation transfer at 3.0 Tesla: preliminary results in patients with low-back pain. Eur Radiol 23(3):861–868
Urban JP, McMullin JF (1985) Swelling pressure of the inervertebral disc: influence of proteoglycan and collagen contents. Biorheology 22(2):145–157
Lyons G, Eisenstein SM, Sweet MB (1981) Biochemical changes in intervertebral disc degeneration. Biochim Biophys Acta 673(4):443–453
Kim M, Chan Q, Anthony MP, Cheung KM, Samartzis D, Khong PL (2011) Assessment of glycosaminoglycan distribution in human lumbar intervertebral discs using chemical exchange saturation transfer at 3 T: feasibility and initial experience. NMR Biomed 24(9):1137–1144
Müller-Lutz A, Schleich C, Schmitt B, Topgöz M, Pentang G, Antoch G, Wittsack HJ, Miese F (2015) Improvement of gagCEST imaging in the human lumbar intervertebral disc by motion correction. Skeletal Radiol 44(4):505–511
Wei W, Jia G, Flanigan D, Zhou J, Knopp MV (2014) Chemical exchange saturation transfer MR imaging of articular cartilage glycosaminoglycans at 3 T: accuracy of B 0 field inhomogeneity corrections with gradient echo method. Magn Reson Imaging 32(1):41–47
Kim M, Gillen J, Landman BA, Zhou J, van Zijl PC (2009) Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments. Magn Reson Med 61(6):1441–1450
Schuenke P, Windschuh J, Roeloffs V, Ladd ME, Bachert P, Zaiss M (2016) Simultaneous mapping of water shift and B 1 (WASABI)-application to field-inhomogeneity correction of CEST MRI data. Magn Reson Med. https://doi.org/10.1002/mrm.26133
Müller-Lutz A, Schleich C, Schmitt B, Antoch G, Matuschke F, Quentin M, Wittsack HJ, Miese F (2016) Gender, BMI and T 2 dependencies of glycosaminoglycan chemical exchange saturation transfer in intervertebral discs. Magn Reson Imaging 34(3):271–275
Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N (2001) Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine 26(17):1873–1878 (Phila Pa 1976)
Windschuh J, Zaiss M, Meissner JE, Paech D, Radbruch A, Ladd ME, Bachert P (2015) Correction of B 1-inhomogeneities for relaxation-compensated CEST imaging at 7 T. NMR Biomed 28(5):529–537
Schleich C, Müller-Lutz A, Matuschke F, Sewerin P, Sengewein R, Schmitt B, Ostendorf B, Wittsack HJ, Stanke K, Antoch G, Miese F (2015) Glycosaminoglycan chemical exchange saturation transfer of lumbar intervertebral discs in patients with spondyloarthritis. J Magn Reson Imaging 42(4):1057–1063
Yoon MA, Hong SJ, Kang CH, Ahn KS, Kim BH (2016) T 1rho and T2 mapping of lumbar intervertebral disc: correlation with degeneration and morphologic changes in different disc regions. Magn Reson Imaging 34(7):932–939
van Zijl PC, Yadav NN (2011) Chemical exchange saturation transfer (CEST): what is in a name and what isn’t? Magn Reson Med 65(4):927–948
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Study conception and design: A.M.-L., J.S., M.Z., H.-J.W., C.S. Acquisition of data: A.M.-L. Analysis and interpretation of data: A.M.-L., A.L., J.S., M.Z., J.B., H.-J.W., C.S. Drafting of manuscript: A.M.-L., A.L., J.S., J.B., H.-J.W., C.S. Critical revision: A.M.-L., A.L., J.S., J.B., H.-J.W., C.S.
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Müller-Lutz, A., Ljimani, A., Stabinska, J. et al. Comparison of B0 versus B0 and B1 field inhomogeneity correction for glycosaminoglycan chemical exchange saturation transfer imaging. Magn Reson Mater Phy 31, 645–651 (2018). https://doi.org/10.1007/s10334-018-0689-5
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DOI: https://doi.org/10.1007/s10334-018-0689-5