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Obstructive sleep apnea syndrome is associated with metabolic syndrome and inflammation

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Abstract

Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular morbidity and mortality. However, the underlying mechanism is unclear. In this cross-sectional study, we investigated the influence of OSA on metabolic syndrome (MetS) and inflammation, which were considered as cardiovascular risks. A total of 144 consecutive male patients who underwent standard polysomnography were enrolled. Fasting blood samples were obtained from all patients for glucose, high-sensitivity C-reactive protein (hs-CRP) and lipids measurement. A metabolic score was established as the total number of the positive diagnostic criteria of metabolic syndrome for each patient. Systolic blood pressure, diastolic blood pressure, fasting glucose, hs-CRP and metabolic score significantly increased with the aggravation of OSA severity. Metabolic score increased from 1.74 ± 1.20 to 2.89 ± 0.99 with OSA severity (p = 0.000). hs-CRP increased from 0.68 (0.43–1.10) to 1.44 (0.62–4.02) mg/L with OSA severity (p = 0.002). After adjustment for confounders, apnea–hypopnea index and body mass index (BMI) were the major contributing factors for metabolic score (β = 0.257, p = 0.003 and β = 0.344, p = 0.000, respectively), lowest O2 saturation and BMI were the independent predictors of hs-CRP (β = −0.255, p = 0.003 and β = 0.295, p = 0.001, respectively). OSA is independently associated with sum of metabolic components and hs-CRP.

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Acknowledgments

This work was supported by grant C07100008 for natural science foundation from Fujian province of China. We would like to thank Bin Yang for assistance with blood analysis. Xiao-Bin Zhang is thanked for his help with statistics.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Fujian Provincial Sleep-Disordered Breathing Clinic Center, Fuzhou, Fujian Province, People’s Republic of China

    Qi-Chang Lin, Li-Da Chen, Yao-Hua Yu, Kai-Xiong Liu & Shao-Yong Gao

  2. Laboratory of Respiratory Disease of the Fujian Medical University, Fuzhou, Fujian Province, People’s Republic of China

    Qi-Chang Lin, Li-Da Chen, Yao-Hua Yu, Kai-Xiong Liu & Shao-Yong Gao

  3. Department of Respiratory Medicine, The First Affiliated Hospital of Fujian Medical University, No. 20, Chazhong Road, Taijiang District, Fuzhou, Fujian Province, 350005, People’s Republic of China

    Qi-Chang Lin, Li-Da Chen, Yao-Hua Yu, Kai-Xiong Liu & Shao-Yong Gao

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  1. Qi-Chang Lin
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  2. Li-Da Chen
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Correspondence to Qi-Chang Lin.

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Lin, QC., Chen, LD., Yu, YH. et al. Obstructive sleep apnea syndrome is associated with metabolic syndrome and inflammation. Eur Arch Otorhinolaryngol 271, 825–831 (2014). https://doi.org/10.1007/s00405-013-2669-8

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  • DOI: https://doi.org/10.1007/s00405-013-2669-8

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