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Second re-irradiation for DIPG progression, re-considering “old strategies” with new approaches

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Abstract

Diffuse intrinsic pontine glioma (DIPG) is an aggressive infiltrative glioma for which no curative therapy is available. Radiation therapy (RT) is the only potentially effective intervention in delaying tumor progression, but only transiently. At progression, re-irradiation is gaining popularity as an effective palliative therapy. However, at second progression, exclusive symptomatic treatment is usually offered. Here we report two patients with DIPG at second progression who were treated with a second re-irradiation course with good response. Importantly, treatment was well tolerated with no irradiation associated acute toxicity identified.

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Authors and Affiliations

  1. Pediatric Neuro-Oncology, Department of Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Passeig Sant Joan de Déu 2, 08950, Barcelona, Spain

    Andres Morales La Madrid & Ofelia Cruz Martinez

  2. Pediatric Hematology and Oncology, Hospital Sant Joan de Déu, Barcelona, Spain

    Andres Morales La Madrid, Vicente Santa-María, Ofelia Cruz Martinez & Jaume Mora

  3. Pediatric Neurosurgery, Hospital Sant Joan de Déu, Barcelona, Spain

    Patricia Puerta Roldan & Antonio Guillen Quesada

  4. Department of Pathology, Hospital Sant Joan de Déu, Barcelona, Spain

    Mariona Suñol Capella

  5. Developmental Tumor Biology Laboratory, Institut de Recerca Pediàtrica—Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain

    Carmen de Torres Gomez-Pallete

  6. Neuro-Oncology Department, Division of Pediatric Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada

    Alvaro Lassaletta & Eric Bouffet

  7. Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Canada

    Normand Laperriere

  8. Department of Radiation Oncology, Institut Oncològic Teknon and Institut Català d’Oncologia, Barcelona, Spain

    Salvador Villà

Authors
  1. Andres Morales La Madrid
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  2. Vicente Santa-María
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  3. Ofelia Cruz Martinez
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  4. Jaume Mora
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  5. Patricia Puerta Roldan
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  6. Antonio Guillen Quesada
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  7. Mariona Suñol Capella
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  8. Carmen de Torres Gomez-Pallete
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  9. Alvaro Lassaletta
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  10. Normand Laperriere
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  11. Salvador Villà
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  12. Eric Bouffet
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Corresponding author

Correspondence to Andres Morales La Madrid.

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The authors declare no conflicts of interest.

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Morales La Madrid, A., Santa-María, V., Cruz Martinez, O. et al. Second re-irradiation for DIPG progression, re-considering “old strategies” with new approaches. Childs Nerv Syst 33, 849–852 (2017). https://doi.org/10.1007/s00381-017-3352-y

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  • DOI: https://doi.org/10.1007/s00381-017-3352-y

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