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Die onkologische Ösophagusresektion und -rekonstruktion

Offen, Hybrid, MIC oder Robotik?

Oncologic esophageal resection and reconstruction

Open, hybrid, minimally invasive or robotic?

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Zusammenfassung

Zunehmend werden minimalinvasive Resektionen in der onkologischen Chirurgie des Ösophaguskarzinoms eingesetzt. Die neue deutsche S3-Leitlinie konstatiert, dass sowohl die Ösophagektomie als auch die Rekonstruktion des Ösophagus minimalinvasiv oder in Kombination mit offenen Prozeduren (Hybridtechnik) ausgeführt werden kann. Auf die aktuelle Wertigkeit der unterschiedlichen Techniken von der komplett minimalinvasiven Ösophagektomie über die Hybridoperation bis zur Robotik wird dabei nicht eingegangen. Ziel dieser Übersichtsarbeit ist der kritische Vergleich der unterschiedlichen Techniken anhand aktueller Evidenz. Minimalinvasive Verfahren der onkologischen Ösophagusresektion sind in erfahrenen Händen sicher und zeigen zahlreiche Vorteile der postoperativen Rekonvaleszenz auf. Die laparoskopische Gastrolyse mit intraabdomineller Lymphadenektomie und muskelschonender, anterolateraler Minithorakotomie (auch via VATS als Single-port-Technik) im Sinne eines Hybridverfahrens führt ebenfalls zu einer deutlichen Reduktion der postoperativen Morbidität und bietet die Möglichkeit der erweiterten mediastinalen Lymphadenektomie, welche thorakoskopisch einer hohen Expertise bedarf. Die Robotikösophagektomie wird derzeit in Deutschland nur in wenigen Kliniken durchgeführt. Hinzuweisen ist auf die fehlende Evidenz für die Ösophaguschirurgie anhand von Studien sowie die hohen Investitions- und Betriebskosten des Robotiksystems.

Abstract

Minimally invasive resections are increasingly employed in oncologic surgery for esophageal carcinoma. The new German S3 guideline states that esophagectomy, as well as reconstruction of the esophagus, can be performed minimally invasively or in combination with open techniques (hybrid). However, the current value of different techniques – ranging from complete minimally invasive esophagectomy over hybrid to robotic surgery – remains unregarded.

This review provides a critical comparison of these techniques based on current evidence. Minimally invasive procedures of oncologic esophageal resection are safe in experienced hands and show numerous advantages with regard to postoperative reconvalescence. Laparoscopic gastrolysis with intra-abdominal lymphadenectomy and muscle sparing as well as anterolateral mini-thoracotomy (also via VATS as single-port technique) as a hybrid method also result in a relevant reduction of postoperative mortality and offer the possibility of extended mediastinal lymphadenectomy, which requires a high level of expertise when performed thoracoscopically. At present, robotic esophagectomy is applied in only a few clinics in Germany. A lack of evidence based on studies for esophageal surgery, as well as high acquisition and operating costs of the robotic system, have to be taken into account.

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Literatur

  1. Hoeppner J, Marjanovic G, Glatz T, Kulemann B, Hopt UT (2014) Hybrid laparoscopic thoracotomic esophagectomy with intrathoracic esophagogastric anastomosis. Chirurg 85(7):628–635

    Article  CAS  PubMed  Google Scholar 

  2. Runkel N, Walz M, Ketelhut M (2015) Abdominothoracic esophageal resection according to Ivor Lewis with intrathoracic anastomosis: standardized totally minimally invasive technique. Chirurg 86(5):468–475

    Article  CAS  PubMed  Google Scholar 

  3. Gockel I, Ahlbrand CJ, Arras M, Schreiber EM, Lang H (2015) Quality management and key performance indicators in oncologic esophageal surgery. Dig Dis Sci 60(12):3536–3544

    Article  PubMed  Google Scholar 

  4. Porschen R, Buck A, Fischbach W, Gockel I, Görling U, Grenacher L, Hollerbach S, Hölscher A, Körber J, Messmann H, Meyer HJ, Miehlke A, Möhler M, Nöthlings U, Pech O, Schmidberger H, Schmidt M, Stahl M, Stuschke M, Thuss-Patience P, Trojan J, Vanhoefer U, Weimann A, Wenz F, Wullstein C (2015) S3-Leitlinie Diagnostik und Therapie der Plattenepithelkarzinome und Adenokarzinome des Ösophagus (Langversion 1.0 – September 2015, AWMF-Registriernummer: 021/023OL). Z Gastroenterol 53(11):1288–1347

    Article  CAS  PubMed  Google Scholar 

  5. Siewert JR, Stein HJ (1998) Classification of adenocarcinoma of the esophagogastric junction. Br J Surg 85(11):1457–1459

    Article  CAS  PubMed  Google Scholar 

  6. Orringer MB, Marshall B, Chang AC, Lee J, Pickens A, Lau CL (2007) Two thousand transhiatal esophagectomies: changing trends, lessons learned. Ann Surg 246(3):363–372

    Article  PubMed  PubMed Central  Google Scholar 

  7. Lewis I (1946) The surgical treatment of carcinoma of the esophagus with special reference to a new operation for growths of the middle third. Br J Surg 34:18–31

    Article  CAS  PubMed  Google Scholar 

  8. McKeown KC (1976) Total three-stage oesophagectomy for cancer of the oesophagus. Br J Surg 63(4):259–262

    Article  CAS  PubMed  Google Scholar 

  9. Siewert JR, Stein HJ (1999) Lymph-node dissection in squamous cell esophageal cancer – who benefits? Langenbecks Arch Surg 384(2):141–148

    Article  CAS  PubMed  Google Scholar 

  10. Siewert JR, Stein HJ, Bottcher K (1996) Lymphadenectomy in tumors of the upper gastrointestinal tract. Chirurg 67(9):877–888

    Article  CAS  PubMed  Google Scholar 

  11. Robb WB, Dahan L, Mornex F, Maillard E, Thomas PA, Meunier B, Boige V, Pezet D, Le Brun-Ly V, Bosset JF, Mabrut JY, Triboulet JP, Bedenne L, Seitz JF, Mariette C, Fédération Française de Cancérologie Digestive, Société Française de Radiothérapie Oncologique, Union des Centres de Lutte Contre le Cancer, Groupe Coopérateur Multidisciplinaire en Oncologie, French EsoGAstric Tumour working group, Fédération de Recherche En Chirurgie (2015) Impact of neoadjuvant chemoradiation on lymph node status in esophageal cancer: post hoc analysis of a randomized controlled trial. Ann Surg 261(5):902–908

    Article  PubMed  Google Scholar 

  12. Koen Talsma A, Shapiro J, Looman CW, van Hagen P, Steyerberg EW, van der Gaast A, van Berge Henegouwen MI, Wijnhoven BP, van Lanschot JJ, CROSS Study Group, Hulshof MC, van Laarhoven HW, Nieuwenhuijzen GA, Hospers GA, Bonenkamp JJ, Cuesta MA, Blaisse RJ, Busch OR, ten Kate FJ, Creemers GJ, Punt CJ, Plukker JT, Verheul HM, van Dekken H, van der Sangen MJ, Rozema T, Biermann K, Beukema JC, Piet AH, van Rij CM, Reinders JG, Tilanus HW (2014) Lymph node retrieval during esophagectomy with and without neoadjuvant chemoradiotherapy: prognostic and therapeutic impact on survival. Ann Surg 260(5):786–792

    Article  CAS  PubMed  Google Scholar 

  13. van Hagen P, Hulshof MC, van Lanschot JJ, Steyerberg EW, van Berge Henegouwen MI, Wijnhoven BP, Richel DJ, Nieuwenhuijzen GA, Hospers GA, Bonenkamp JJ, Cuesta MA, Blaisse RJ, Busch OR, ten Kate FJ, Creemers GJ, Punt CJ, Plukker JT, Verheul HM, Spillenaar Bilgen EJ, van Dekken H, van der Sangen MJ, Rozema T, Biermann K, Beukema JC, Piet AH, van Rij CM, Reinders JG, Tilanus HW, van der Gaast A, CROSS Group (2012) Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med 366(22):2074–2084

    Article  PubMed  Google Scholar 

  14. Lagergren J, Mattsson F, Zylstra J, Chang F, Gossage J, Mason R, Lagergren P, Davies A (2016) Extent of lymphadenectomy and prognosis after esophageal cancer surgery. JAMA Surg 151(1):32–39

    Article  PubMed  Google Scholar 

  15. Cuschieri A, Shimi S, Banting S (1992) Endoscopic oesophagectomy through a right thoracoscopic approach. J R Coll Surg Edinb 37(1):7–11

    CAS  PubMed  Google Scholar 

  16. Luketich J, Alvelo-Rivera M, Buenaventura P, Christie NA, McCaughan JS, Little VR, Schauer PR, Close JM, Fernando HC (2003) Minimally invasive esophagectomy: outcomes in 222 patients. Ann Surg 238(4):486–495

    PubMed  PubMed Central  Google Scholar 

  17. Palanivelu C, Prakash A, Senthilkumar R, Senthilnathan P, Parthasarathi R, Rajan PS, Venkatachlam S (2006) Minimally invasive esophagectomy: thoracoscopic mobilization of the esophagus and mediastinal lymphadenectomy in prone position – experience of 130 patients. J Am Coll Surg 203(1):7–16

    Article  PubMed  Google Scholar 

  18. Luketich JD, Pennathur A, Awais O, Levy RM, Keeley S, Shende M, Christie NA, Weksler B, Landreneau RJ, Abbas G, Schuchert MJ, Nason KS (2012) Outcomes after minimally invasive esophagectomy, review over 1000 patients. Ann Surg 256(1):95–103

    Article  PubMed  PubMed Central  Google Scholar 

  19. Shen Y, Zhang Y, Tan L, Feng M, Wang H, Khan MA, Liang M, Wang Q (2012) Extensive mediastinal lymphadenectomy during minimally invasive esophagectomy optimal results from a single center. J Gastrointest Sug 16(4):715–721

    Article  Google Scholar 

  20. Luketich JD, Pennathur A, Franchetti Y, Catalano PJ, Swanson S, Sugarbaker DJ, De Hoyos A, Maddaus MA, Nguyen NT, Benson AB, Fernando HC (2015) Minimally invasive esophagectomy: results of a prospective phase II multicenter trial-the eastern cooperative oncology group (E2202) study. Ann Surg 261(4):702–707

    Article  PubMed  PubMed Central  Google Scholar 

  21. Wullstein C, Ro-Papanikolaou HY, Klingebiel C, Ersahin K, Carolus R (2015) Minimally invasive techniques and hybrid operations for esophageal cancer. Viszeralmedizin 31(5):331–336

    Article  PubMed  PubMed Central  Google Scholar 

  22. Xiong WL, Li R, Lei HK, Jiang ZY (2015) Comparison of outcomes between minimally invasive oesophagectomy and open oesophagectomy for oesophageal cancer. ANZ J Surg. doi:10.1111/ans.13334 (Epub ahead of print)

    PubMed  Google Scholar 

  23. Bailey L, Khan O, Willows E, Somers S, Mercer S, Toh S (2013) Open and laparoscopically assisted oesophagectomy: a prospective comparative study. Eur J Cardiothorac Surg 43(2):268–273

    Article  PubMed  Google Scholar 

  24. Biere SS, van Berge Henegouwen MI, Maas KW, Bonavina L, Rosman C, Garcia JR, Gisbertz SS, Klinkenbijl JH, Hollmann MW, de Lange ES, Bonjer HJ, van der Peet DL, Cuesta MA (2012) Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial. Lancet 379(9829):1887–1982

    Article  PubMed  Google Scholar 

  25. Maas KW, Cuesta MA, van Berge Henegouwen MI, Roig J, Bonavina L, Rosman C, Gisbertz SS, Biere SS, van der Peet DL, Klinkenbijl JH, Hollmann MW, de Lange ES, Bonjer HJ (2015) Quality of life and late complications after minimally invasive compared to open esophagectomy: Results of a randomized trial. World J Surg 39(8):1986–1993

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Wang Y, Chen C (2016) Survival following video-assisted thoracoscopic versus open esophagectomy for esophageal carcinoma. J BUON 21(2):427–433

    PubMed  Google Scholar 

  27. Briez N, Piessen G, Bonnetain F, Brigand C, Carrere N, Collet D, Doddoli C, Flamein R, Mabrut JY, Meunier B, Msika S, Perniceni T, Peschaud F, Prudhomme M, Triboulet JP, Mariette C (2011) Open versus laparoscopically-assisted oesophagectomy for cancer: a multicentre randomised controlled phase III trial – the MIRO trial. BMC Cancer 11:310. doi:10.1186/1471-2407-11-310

    Article  PubMed  PubMed Central  Google Scholar 

  28. Mariette C, Meunier B, Pezet D, Dalban C, Collet D, Thomas PA, Brigand C, Perniceni T, Carrere N, Bonnetain F, Piessen G (2015) Hybrid minimally invasive versus open oesophagectomy for patients with oesophageal cancer: A muldicenter, open-label, randomized phase III controlled trial, the MIRO trial. 2015 ASCO Gastrointestinal Cancers Symposium. J Clin Oncol 33(Supplement 3):Abstract 5

    Article  Google Scholar 

  29. Messager M, Pasquer A, Duhamel A, Caranhac G, Piessen G, Mariette C, on behalf of the FREGAT working group – FRENCH (2015) Laparoscopic gastric mobilization reduces postoperative mortality after esophageal cancer surgey: A French Nationwide Study. Paper of the 22nd Annual ESA Meeting. Ann Surg 262(5):817–823

    Article  PubMed  Google Scholar 

  30. Miyata K, Fukaya M, Itatsu K, Abe T, Nagino M (2016) Muscle sparing thoracotomy for esophageal cancer: a comparison with posterolateral thoracotomy. Surg Today 46(7):807–814

    Article  PubMed  Google Scholar 

  31. Metcalfe C, Avery K, Berrisford R, Barham P, Noble SM, Fernandez AM, Hanna G, Goldin R, Elliott J, Wheatley T, Sanders G, Hollowood A, Falk S, Titcomb D, Streets C, Donovan JL, Blazeby JM (2016) Comparing open and minimally invasive surgical procedures for oesophagectomy in the treatment of cancer: the ROMIO (Randomised Oesophagectomy: Minimally Invasive or Open) feasibility study and pilot trial. Health Technol Assess 20(48):1–68

    Article  PubMed  PubMed Central  Google Scholar 

  32. Palazzo F, Rosato EL, Chaudhary A, Evans NR 3rd, Sendecki JA, Keith S, Chojnacki KA, Yeo CJ, Berger AC (2015) Minimally invasive esophagectomy provides significant survival advantage compared with open or hybrid esophagectomy for patients with cancers of the esophagus and gastroesophageal junction. J Am Coll Surg 220(4):672–679

    Article  PubMed  Google Scholar 

  33. Bonavina L, Scolari F, Aiolfi A, Bonitta G, Sironi A, Saino G, Asti E (2016) Early outcome of thoracoscopic and hybrid esophagectomy: Propensity-matched comparative analysis. Surgery 159(4):1073–1081

    Article  PubMed  Google Scholar 

  34. Boone J, Schipper ME, Moojen WA, Borel Rinkes IH, Cromheecke GJ, van Hillegersberg R (2009) Robot-assisted thoracoscopic oesophagectomy for cancer. Br J Surg 96(8):878–886

    Article  CAS  PubMed  Google Scholar 

  35. van Hillegersberg R, Seesing MF, Brenkman HJ, Ruurda JP (2016) Robot-assisted minimally invasive esophagectomy. Chirurg 87(8):635–642

    Article  PubMed  Google Scholar 

  36. van der Sluis PC, Ruurda JP, van der Horst S, Verhage RJ, Besselink MG, Prins MJ, Haverkamp L, Schippers C, Rinkes IH, Joore HC, Ten Kate FJ, Koffijberg H, Kroese CC, van Leeuwen MS, Lolkema MP, Reerink O, Schipper ME, Steenhagen E, Vleggaar FP, Voest EE, Siersema PD, van Hillegersberg R (2012) Robot-assisted minimally invasive thoraco-laparoscopic esophagectomy versus open transthoracic esophagectomy for resectable esophageal cancer, a randomized controlled trial (ROBOT trial). Trials 30(13):230. doi:10.1186/1745-6215-13-230

    Article  Google Scholar 

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I. Gockel und D. Lorenz geben an, dass kein Interessenkonflikt besteht.

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Gockel, I., Lorenz, D. Die onkologische Ösophagusresektion und -rekonstruktion. Chirurg 88, 496–502 (2017). https://doi.org/10.1007/s00104-016-0364-1

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