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Life course socioeconomic adversities and 10-year risk of cardiovascular disease: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health

  • Original Article
  • Published:
International Journal of Public Health

Abstract

Objectives

To investigate whether life course exposure to adverse socioeconomic positions (SEP) as well as maintaining a low SEP or decreasing the SEP intra- and intergeneration was associated with an increased 10-year cardiovascular disease (CVD) risk predicted by the Framingham Risk Score.

Methods

This is a cross-sectional analysis of baseline data (2008–2010) of 13,544 active workers from ELSA-Brasil cohort. Maternal education, leg length, social class of first occupation and education were used to evaluate childhood, youth and adulthood SEP.

Results

After considering adulthood SEP, exposure to early-life low SEP remained associated with an increased 10-year CVD risk. The 10-year CVD risk also rose as the number of exposures to low SEP throughout life increased. Compared to individuals in high-stable intragenerational trajectory, those in upward, downward, or stable low trajectory presented higher 10-year CVD risk. Increasing individuals’ SEP over generation showed no increased risk of 10-year CVD risk compared to individuals in high-stable trajectory.

Conclusions

Childhood may be a critical period for exposures to social adversities. Life course low SEP may also affect the 10-year CVD risk via accumulation of risk and social mobility.

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Acknowledgements

We would like to thank all ELSA-Brasil participants for their valuable contribution to this study. This work was supported by the Brazilian Ministry of Health (Department of Science and Technology) and the Ministry of Science, Technology and Innovation (FINEP, Financiadora de Estudos e Projetos, &CNPq, National Research Council), Grants No. 01 06 0010.00, 01 06 0212.00, 01 06 0300.00, 01 06 0278.00, 01 06 0115.00 and 01 06 0071.00. DRS Andrade had postgraduate fellowship; LV Camelo and RCP Reis have postdoctoral research fellowships from the Coordination of Higher Education Personnel Improvement (CAPES). SM Barreto, ALP Ribeiro and L Giatti are research fellows of the National Research Council (CNPq, Grants No. 300159/99-4,309073/2011-1&312371/2013-6). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Authors and Affiliations

  1. Postgraduate Program in Public Health, Faculty of Medicine, Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena, 190, Belo Horizonte, Minas Gerais, 30130-800, Brazil

    Dayse Rodrigues de Sousa Andrade, Lidyane V. Camelo, Rodrigo Citton P. dos Reis, Luana Giatti & Sandhi Maria Barreto

  2. Internal Medicine Department, Faculty of Medicine, Universidade de São Paulo, Av. Doutor Arnaldo, 455, Cerqueira César, São Paulo, São Paulo, 01246-903, Brazil

    Itamar S. Santos

  3. Internal Medicine Department, Faculty of Medicine, and Hospital das Clínicas, Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena, 190, Belo Horizonte, Minas Gerais, 30130-800, Brazil

    Antonio Luiz Ribeiro

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  1. Dayse Rodrigues de Sousa Andrade
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Correspondence to Sandhi Maria Barreto.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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de Sousa Andrade, D.R., Camelo, L.V., dos Reis, R.C.P. et al. Life course socioeconomic adversities and 10-year risk of cardiovascular disease: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health. Int J Public Health 62, 283–292 (2017). https://doi.org/10.1007/s00038-016-0928-3

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  • DOI: https://doi.org/10.1007/s00038-016-0928-3

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