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Double-blind group comparative study of testosterone undecanoate and mesterolone in hypogonadal male patients

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Abstract

A double-blind, randomized, group comparative study was performed in hypogonadal male patients in order to compare the effects on sexual activity and mental state of testosterone undecanoate (TU) and mesterolone (M). The TU-treated group contained 12 patients, and the M-treated group contained 14 patients. The variables of sexual activity and of mental state were scored and evaluated statistically by means of the nonparametric randomization test for 2 independent groups. TU induced a marked improvement of the sexual activity and of the mental state. After 4 weeks of treatment the effects were significantly better than in the M-treated group: libido (p < 0.001), erections (p < 0.01), ejaculations (p < 0.05) and mental state (p < 0.001).

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Authors and Affiliations

  1. Endocrine Unit of the CNR and Postgraduate School of Endocrinology, University of Pisa, via Roma 67, 56100, Pisa, Italy

    M. Luisi & F. Franchi

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  1. M. Luisi
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  2. F. Franchi
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Supported by Grant no. 77.01689.04/115.1130 of the National Research Council (Rome).

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Luisi, M., Franchi, F. Double-blind group comparative study of testosterone undecanoate and mesterolone in hypogonadal male patients. J Endocrinol Invest 3, 305–308 (1980). https://doi.org/10.1007/BF03348281

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  • DOI: https://doi.org/10.1007/BF03348281

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