Abstract
Interstitial low power Nd-YAG laser hyperthermia is a new method with potential for the future treatment of localized neoplasms. A laser fibre is inserted into the tumour. Energy is applied and the tumour is destroyed by heat and phototoxicity. Since most tumours are spherical in shape, the optimal design of the laser fibre tip would be one which caused the light to spread uniformly in all directions. We describe a cone shaped forsted modification of the bare fibre proper (‘the diffuser tip’), that produces coagulation lesions of spherical shape. In vitro experiments show that the lesions were highly reproducible with respect to size and shape, and an excellent doseresponse relationship was observed. The largest lesion produced was achieved with 4 W for 1800 s and measured 44 mm in diameter. By comparison with lesions produced with the non-modified fibre (‘the endfire fibre’) it is concluded that the diffuser tip is superior to the endfire tip, since the latter produces cylinder shaped lesions. Based on these observations it seems that the diffuser tip will be advantageous, e.g. in the treatment of liver metastases.
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Nolsøe, C., Torp-Pedersen, S., Olldag, E. et al. Bare fibre low power Nd-YAG laser interstitial hyperthermia. Comparison between diffuser tip and non-modified tip. An in vitro study. Laser Med Sci 7, 1–7 (1992). https://doi.org/10.1007/BF02594043
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DOI: https://doi.org/10.1007/BF02594043