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The metabolism of labeled parathyroid hormone

IV. Autoradiographic studies

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Abstract

Autoradiographs were prepared from tissues of rats sacrificed 10 minutes after injection of biologically active125I-labeled parathyroid hormone. No radioactivity was seen in intestine and muscle. Deposition in liver was diffuse showing some sinusoidal concentrations. Deposition in kidney was high and, nearly all activity appeared in selected tubules (presumably proximal tubules) in the outer third of the cortex. Specific localization was also seen in bone particularly in the cellular layers of periosteum and endosteum adjacent to bony matrix and to some extent in osteocytes.

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References

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Author notes

  1. P. J. Sammon

    Present address: Department of Oral Biology, University of Kentucky College of Dentistry, 40506, Lexington, Kentucky, USA

Authors and Affiliations

  1. Department of Radiation Biology and Biophysics, School of Medicine and Dentistry, University of Rochester, 14642, Rochester, New York, USA

    W. F. Neuman, M. W. Neuman, P. J. Sammon & G. W. Casarett

Authors
  1. W. F. Neuman
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  2. M. W. Neuman
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  3. P. J. Sammon
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  4. G. W. Casarett
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Neuman, W.F., Neuman, M.W., Sammon, P.J. et al. The metabolism of labeled parathyroid hormone. Calc. Tis Res. 18, 263–270 (1975). https://doi.org/10.1007/BF02546245

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  • DOI: https://doi.org/10.1007/BF02546245

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