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Mechanisms of free radical oxidation of unsaturated lipids

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Lipids

Abstract

The primary producs formed from the autoxidation of lipids can be understood based upon a mechanism that involves five different reaction types. These reactions are: reaction of a carbon radical and molecular oxygen, atom transfer of a hydrogen from substrate to the chain carrying peroxyl, fragmentation of the chain carrying peroxyl to give oxygen and a carbon radical, rearrangement of the peroxyl, and cyclization of the peroxyl. The mechanisms of these primary reaction steps has been the focus of extensive research over the past fifty years, and the current level of understanding of these transformations is the subject of this review.

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Abbreviations

GC/MS:

gas chromatography/mass spectrometry

HPLC:

high-pressure liquid chromatography

NMR:

nuclear magnetic resonance

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  1. Paul M. Gross Chemiscal Laboratories, Department of Chemistry, Duke University, 27708, Durham, NC

    Ned A. Porter, Sarah E. Caldwell & Karen A. Mills

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  2. Sarah E. Caldwell
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Porter, N.A., Caldwell, S.E. & Mills, K.A. Mechanisms of free radical oxidation of unsaturated lipids. Lipids 30, 277–290 (1995). https://doi.org/10.1007/BF02536034

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