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Inhibition of arachidonic acid cyclo-oxygenase and lipoxygenase activities of leukocytes by indomethacin and compound BW755C

  • Histamine and Kinins Immunosuppression and Inflammation
  • Lipoxygenase Products: Release and Activities
  • Published:
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Abstract

Arachidonic acid is metabolized via two pathways in leukocytes: cyclo-oxygenase, leading to the stable prostaglandins, and lipoxygenase, leading to hydroxyacids. Indomethacin inhibits the cyclo-oxygenase selectively, whereas compound BW755C (3-amino-1-(m-(trifluoromethyl)phenyl)-2-pyrazoline) inhibits both pathways equally. This offers a possible explanation for the differing activities of these two compounds in inflammatory models in vivo. The patterns of product inhibition by the two compounds support the suggestion that 11-HETE (hydroxy-eicosatetraenoic acid) and 15-HETE can arise by incomplete operation of the cyclo-oxygenase pathway.

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Authors and Affiliations

  1. Departments of Pharmacology and Prostaglandin Research, Wellcome Research Laboratories, BR3 3BS, Beckenham, Kent, UK

    R. W. Randall, K. E. Eakins, G. A. Higgs, J. A. Salmon & J. E. Tateson

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  1. R. W. Randall
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  2. K. E. Eakins
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  3. G. A. Higgs
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  4. J. A. Salmon
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  5. J. E. Tateson
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Randall, R.W., Eakins, K.E., Higgs, G.A. et al. Inhibition of arachidonic acid cyclo-oxygenase and lipoxygenase activities of leukocytes by indomethacin and compound BW755C. Agents and Actions 10, 553–555 (1980). https://doi.org/10.1007/BF02024164

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  • DOI: https://doi.org/10.1007/BF02024164

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