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Luteinization of follicle cysts in rat ovaries as an effect of potassium iodine administration

  • Experimental Biology
  • Published:
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Summary

Following X-irradiation or subtotal castration rats developed follicular cysts of the ovaries; this was accompanied by hyperestrogenism of the organism manifested in the appearance of a constant estrus. In connection with the fact that the development of follicular cysts was caused by insufficiency of the luteinizing function of the hypophysis an attempt was made to stimulate the luteinizing hormone production by microdoses of potassium iodine. The daily administration of KI in a dose of 500 γ provoked within 2 weeks luteinization of follicular cysts and their transformation into corpus luteum. Luteinization of the cysts was accompanied by a marked reduction of the body estrogen level, as manifested by the arrest of estrus with subsequent normalization of the estral cycle or a prolonged diestrus.

Under study were the morphological changes occurring in the follicular cysts during their luteinization under the effect of KI.

the process of gradual transformation of follicular cysts into corpora lutea was followed up.

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Authors and Affiliations

  1. Laboratory of Experimental Hormone Therapy Institute for Experimental and Clinical Oncology, AMN SSSR, Moscow

    I. O. Smirnova

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  1. I. O. Smirnova
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Smirnova, I.O. Luteinization of follicle cysts in rat ovaries as an effect of potassium iodine administration. Bull Exp Biol Med 57, 615–619 (1964). https://doi.org/10.1007/BF00782334

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  • DOI: https://doi.org/10.1007/BF00782334

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