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Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays

III. Antimetabolites, tubulin-binding agents, platinum drugs, amsacrine, L-asparaginase, inteferons, steroids and other miscellaneous antitumour agents

  • Review
  • Drug Stability In Vitro, Antineoplastic Agents
  • Published:
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Summary

The stability of solutions of the antitumour antimetabolites, vinca alkaloids, podophyllotoxins, interferons, steroids and platinum drugs as well as maytansine, asparaginase, amsacrine, flavone-8-acetic acid, mitoguazone, and N-phosphonoacetyl-L-aspartate (PALA) is reviewed. Much of the published work has been done with biological, not stability-indicating, assays; thus, the relevant results should be used with caution. With this proviso, almost all of these drugs can be stored in solution for several days at room temperature or 4°C. Most reports also suggest that the drugs that have been tested are stable when frozen in solution. For a number of the drugs, particular precautions are required; for instance, amsacrine should not be mixed with chloride-containing solutions, whereas cisplatin is most stable in solutions containing >0.1 M chloride.

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  1. Bath Cancer Research Unit, Royal United Hospital, Combe Park, BA1 3NG, Bath, England

    Andrew G. Bosanquet

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Bosanquet, A.G. Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. Cancer Chemother. Pharmacol. 23, 197–207 (1989). https://doi.org/10.1007/BF00451642

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