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Chemoimmunotherapeutic effect of cyclophosphamide on the highly metastatic MAT 13762 tumor

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Summary

We have observed that cyclophosphamide (CY) treatment of 13762 mammary adenocarcinoma tumor-bearing rats was found to cause tumor regression. Tumor-bearing animals cured with three low doses of CY were partially immune against IV and SC challenge with a high dose of 13762 cells. This immune protection mechanism in CY-cured animals appears to be a T (Ig−) cell-mediated response. Irradiated rats reconstituted with CY-cured animal spleen cells were also partially protected against IV and SC challenge with 13762 cells, whereas irradiated rats reconstituted with CY-control animal spleen cells were not. In vitro primary and secondary cell-mediated cytotoxic activity of CY-cured spleen cells against target 13762 cells was low. The possible relevance of this tumor-model study is in the understanding of CY-induced tumor immune response and its role in preventing metastases or perhaps recurrent tumor growth.

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Authors and Affiliations

  1. Division of Surgical Oncology, John Wayne Clinic, Jonsson Comprehensive Cancer Center, Armand Hammer Laboratories, UCLA School of Medicine, 90024, Los Angeles, CA, USA

    Dave S. B. Hoon

  2. Department of Experimental Pathology, John Curtin School of Medical Research, Canberra, Australia

    Ian A. Ramshaw

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  1. Dave S. B. Hoon
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  2. Ian A. Ramshaw
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Hoon, D.S.B., Ramshaw, I.A. Chemoimmunotherapeutic effect of cyclophosphamide on the highly metastatic MAT 13762 tumor. Cancer Immunol Immunother 20, 175–178 (1985). https://doi.org/10.1007/BF00205685

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  • DOI: https://doi.org/10.1007/BF00205685

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