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DNA-Binding and Antimicrobial Studies of Molybdenum Complexes

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Next Generation DNA Led Technologies

Part of the book series: SpringerBriefs in Applied Sciences and Technology ((BRIEFSFOMEBI))

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Abstract

Molybdenum complexes were synthesized and characterized for their purity by various physico-chemical methods like IR, Electronic, NMR Spectral studies. The interaction of complex with calf Thymus DNA (CT-DNA) was studied by using absorption, emission, Spectral methods, thermal denaturation and viscometry studies. The results suggest that the Mo(V) complex intercalates into DNA base pairs via the dithiophosphamate ligand Antimicrobial activity of complexes against certain microbial species has been carried out by serial dilution method to evaluate the MIC (Minimum inhibitory concentration) value. Results showed that Metal complexes are most active as compared to ligand fragments.

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Authors and Affiliations

  1. Bioinorganic Research Laboratory, Department of Chemistry, D.S. College, Aligarh, 202001, Uttar Pradesh, India

    V. K. Srivastava

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  1. V. K. Srivastava
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Correspondence to V. K. Srivastava .

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Editors and Affiliations

  1. AP Police Academy, Hyderabad, India

    Sharada Avadhanam

  2. RA-BioAxis DNA Research Centre (P) Ltd., Hyderabad, India

    G. Jyothsna

  3. Private Limited, BioAxis DNA Research Centre, Hyderabad, India

    Amita Kashyap

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Srivastava, V.K. (2016). DNA-Binding and Antimicrobial Studies of Molybdenum Complexes. In: Avadhanam, S., Jyothsna, G., Kashyap, A. (eds) Next Generation DNA Led Technologies. SpringerBriefs in Applied Sciences and Technology(). Springer, Singapore. https://doi.org/10.1007/978-981-287-670-6_11

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  • DOI: https://doi.org/10.1007/978-981-287-670-6_11

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-287-669-0

  • Online ISBN: 978-981-287-670-6

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