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Cysteine Proteases of Parasitic Helminths

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Pathophysiological Aspects of Proteases

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Abstract

Cysteine protease and/or thiol peptidase/sulphydryl peptidase/cysteinyl peptidase invariably contain cysteine at their active site and hence collectively termed as cathepsins. This proteolytic enzyme, secreted and/or regurgitated/excreted by the in situ invasive forms of metazoan parasites of men and domestic livestock, often involve in the host tissue penetration, digestion of nutrients, and their availability to the parasite for its growth and development, evasion of host defense, and in of late documented their significant role in detection of in situ parasites at an early developmental stage(s) [Immunodiagnosis] beside an important entity to develop immunoprotection strategies against the livestock diseases, so much so, to contain and curb the colossal recurring losses, incidental to widely prevalent parasitic disease, to the fast developing livestock products based food industry in the developing world. Herein, the authors discuss the historical background, molecular structure, and classification of cathepsin proteases and update advancements in exploiting the enzyme for early diagnosis and planning immunoprotection strategies against metazoan parasitic diseases with special reference to tropical fasciolosis.

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Authors and Affiliations

  1. Department of Veterinary Parasitology, College of Veterinary Science & A. H., Nanaji Deshmukh Veterinary Science University, South Civil Lines, Jabalpur, 482001, Madhya Pradesh, India

    Alok K. Dixit

  2. Department of Veterinary Medicine, College of Veterinary Science & A. H., Nanaji Deshmukh Veterinary Science University, South Civil Lines, Jabalpur, 482001, Madhya Pradesh, India

    Pooja Dixit

  3. 843-44, Ranisati Nagar, P.O. Shyam Nagar, Ajmer Road, Jaipur, 302019, Rajasthan, India

    Ramji L. Sharma

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  2. Pooja Dixit
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  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Institute of Cardiovascular Sciences, University of Manitoba, Manitoba, Canada

    Naranjan S. Dhalla

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Dixit, A.K., Dixit, P., Sharma, R.L. (2017). Cysteine Proteases of Parasitic Helminths. In: Chakraborti, S., Dhalla, N. (eds) Pathophysiological Aspects of Proteases. Springer, Singapore. https://doi.org/10.1007/978-981-10-6141-7_29

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