Skip to main content
SpringerLink
Log in

Combination by Hyperthermia and Radiotherapy and/or Chemo-radiotherapy: Gyneology Cancer

  • Chapter
  • First Online:
Hyperthermic Oncology from Bench to Bedside

  • 687 Accesses

Abstract

Six randomized clinical trials comparing therapeutic outcomes of hyperthermia combined with radiotherapy with radiotherapy alone in patients with cervical cancer have been published since 1987, of which four showed significant better complete response, locoregional tumor control, and/or disease-free survival rates in the hyperthermia-combined radiotherapy arms than in the sole radiotherapy arms. One trial showed a trend of better locoregional tumor control in the hyperthermia-combined arm and one did not show any benefit of the hyperthermia-combination therapy. First, I summarize the results of these randomized clinical trials and discuss the effectiveness and safety of hyperthermia-combined treatment for cervical cancer. On the other hand, prognostic factors associated with outcomes of thermo-radiotherapy in advanced cervical carcinoma have also been studied and some promising biomarkers have been identified hitherto. Second, I present our comprehensive molecular genetic approach to identify prognostic biomarkers of thermoradiotherapy for cervical cancer patients and discuss them from an aspect of molecular biology.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Steven E, Waggoner SE. Cervical cancer. Lancet. 2003;361:2217–25.

    Article  Google Scholar 

  2. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359–86.

    Article  CAS  PubMed  Google Scholar 

  3. Rotman M, Pajak TF, Choi K, Clery M, Marcial V, Grigsby PW, et al. Prophylactic extended-field irradiation of para-aortic lymph nodes in stages IIB and bulky IB and IIA cervical carcinomas. Ten-year treatment results of RTOG 79–20. JAMA. 1995;274(5):387–93.

    Article  CAS  PubMed  Google Scholar 

  4. Perez CA, Grigsby PW, Chao KS, Mutch DG, Lockett MA. Tumor size, irradiation dose, and long-term outcome of carcinoma of uterine cervix. Int J Radiat Oncol Biol Phys. 1998;41(2):307–17.

    Article  CAS  PubMed  Google Scholar 

  5. Harima Y, Nagata K, Harima K, Ostapenko VV, Tanaka Y, Sawada S. A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma. Int J Hyperthermia. 2001;17:97–105.

    Article  CAS  PubMed  Google Scholar 

  6. Van Der Zee J, González González D, Van Rhoon GC, Van Dijk JDP, Van Putten WLJ, Hart AAM. Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomized, multicentre trial. Lancet. 2000;355:1119–25.

    Article  PubMed  Google Scholar 

  7. Datta NR, Bose AK, Kapoor HK. Thermoradiotherapy in the management of carcinoma of the cervix (IIIB): a controlled clinical study. Ind Med Gaz. 1987;121:68–71.

    Google Scholar 

  8. Sharma S, Singhal S, Sandhu AP, Ghoshal S, Gupta BD, Yadav NS. Local thermo-radiotherapy in carcinoma cervix: improved local control versus increased incidence of distant metastasis. Asia Oceania J Obstet Gynaecol. 1991;17:5–12.

    Article  CAS  PubMed  Google Scholar 

  9. Chen HW, Jun-Jie F, Wei L. A randomized trial of hyperthermia-radiochemotherapy for uterine cervix cancer. Chin J Clin Oncol. 1997;24:249–51.

    Google Scholar 

  10. Vasanthan A, Mitsumori M, Park JH, Zhi-Fan Z, Yu-Bin Z, Oliynychenko P, et al. Regional hyperthermia combined with radiotherapy for uterine cervical cancers: a multi-institutional prospective randomized trial of the international atomic energy agency. Int J Radiat Oncol Biol Phys. 2005;61:145–53.

    Article  PubMed  Google Scholar 

  11. Ohnishi T, Komatsu K, Tauchi H, Wang X, Takahashi A, Ohnishi K, et al. Heat-induced accumulation of p53 and hsp72 is suppressed in lung fibroblasts from SCID mouse. Int J Radiat Biol. 2000;76:711–15.

    Article  CAS  PubMed  Google Scholar 

  12. Harima Y, Nagata K, Harima K, Oka A, Ostapenko VV, Shikata N, et al. Bax and Bcl-2 protein expression following radiation therapy versus radiation plus thermoradiotherapy in stage IIIB cervical carcinoma. Cancer. 2000;88:132–8.

    Article  CAS  PubMed  Google Scholar 

  13. Samali A, Holmberg CI, Sistonen L, Orrenius S. Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins. FEBS Lett. 1999;461:306–10.

    Article  CAS  PubMed  Google Scholar 

  14. Harima Y, Sawada S, Togashi A, Horikoshi K, Katagiri T, Tsunoda T, et al. Prediction of outcome of advanced cervical cancer to thermoradiotherapy according to expression profiles of 35 genes selected by cDNA microarray analysis. Int J Radiat Oncol Biol Phys. 2004;60:237–48.

    Article  CAS  PubMed  Google Scholar 

  15. Rose PG, Bundy BN, Watkins EB, Thigpen JT, Deppe G, Maiman MA, et al. Concurrent cisplatin-based chemotherapy and radiotherapy for locally advanced cervical cancer. N Engl J Med. 1999;340:1144–53.

    Article  CAS  PubMed  Google Scholar 

  16. Peters III WA, Liu PY, Barrett II RJ, Stock RJ, Monk BJ, Berek JS, et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol. 2000;18:1606–13.

    CAS  PubMed  Google Scholar 

  17. Morris M, Eifel PJ, Lu J, Grigsby PW, Levenback C, Stevens RE, et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N Engl J Med. 1999;340:1137–43.

    Article  CAS  PubMed  Google Scholar 

  18. Keys HM, Bundy BN, Stehman FB, Muderspach LI, Chafe WE, Suggs III CL, et al. Cisplatin, radiation, and adjuvant hysterectomy for bulky Stage IB cervical carcinoma. N Engl J Med. 1999;340:1154–61.

    Article  CAS  PubMed  Google Scholar 

  19. Whitney CW, Sause W, Bundy BN, Malfetano JH, Hannigan EV, Fowler Jr WC, et al. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in Stage IIB–IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study. J Clin Oncol. 1999;17:1339–48.

    CAS  PubMed  Google Scholar 

  20. Pearcey R, Brundage M, Drouin P, Jeffrey J, Johnston D, Lukka H, et al. Phase III trial comparing radical radiotherapy with and without cisplatin chemotherapy in patients with advanced squamous cell cancer of the cervix. J Clin Oncol. 2002;20:966–72.

    Article  CAS  PubMed  Google Scholar 

  21. Grogan M, Thomas GM, Melamed I, Wong FL, Pearcey RG, Joseph PK, et al. The importance of haemoglobin levels during radiotherapy for carcinoma of the cervix. Cancer. 1999;86:1528–36.

    Article  CAS  PubMed  Google Scholar 

  22. Rose PG, Bundy BN. Chemoradiation for locally advanced cervical cancer: does it help? J Clin Oncol. 2002;20:891–3.

    PubMed  Google Scholar 

  23. National Cancer Institute. Concurrent chemoradiation for cervical cancer [clinical announcement]. 1999.

    Google Scholar 

  24. Lutgens L, Van Der Zee J, Pijls-Johannesma M, De Haas-Kock DF, Buijsen J, Mastrigt GA, et al. Combined use of hyperthermia and radiation therapy for treating locally advanced cervix carcinoma. Cochrane Database Syst Rev. 2010;17(3):CD006377.

    Google Scholar 

  25. Westermann AM, Jones EL, Schem BC, Van Der Steen-Banasik EM, Koper P, Mella O, et al. First results of triple-modality treatment combining radiotherapy, chemotherapy, and hyperthermia for the treatment of patients with stage IIB, III, and IVA cervical carcinoma. Cancer. 2005;104:763–70.

    Article  CAS  PubMed  Google Scholar 

  26. Westermann A, Mella O, Van Der Zee J, Jones EL, Van Der Steen-Banasik EM, Koper P, et al. Long-term survival data of triple modality treatment of stage IIB–III–IVA cervical cancer with the combination of radiotherapy, chemotherapy and hyperthermia – an update. Int J Hyperthermia. 2012;28(6):549–53.

    Article  CAS  PubMed  Google Scholar 

  27. Ottilie S, Diaz JL, Horne W, Chang J, Wang Y, Wilson G, et al. Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins. J Biol Chem. 1997;272:30866–72.

    Article  CAS  PubMed  Google Scholar 

  28. Villalva C, Trempat P, Greenland C, Thomas C, Girard JP, Moebius F, et al. Isolation of differentially expressed genes in NPM-ALK-positive anaplastic large cell lymphoma. Br J Haematol. 2002;118:791–8.

    Article  CAS  PubMed  Google Scholar 

  29. Fyles AW, Milocevic M, Wong R, Kavanagh MC, Pintilie M, Sun A, et al. Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol. 1998;48:149–56.

    Article  CAS  PubMed  Google Scholar 

  30. Hutchison GJ, Valentine HR, Loncaster JA, Davidson SE, Hunter RD, Roberts SA, et al. Hypoxia-inducible factor 1α expression as an intrinsic marker of hypoxia: correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix. Clin Cancer Res. 2004;10:8405–12.

    Article  CAS  PubMed  Google Scholar 

  31. Ishikawa H, Sakurai H, Hasegawa M, Mitsuhashi N, Takahashi M, Masuda N, et al. Expression of hypoxic-inducible factor 1α predicts metastasis-free survival after radiation therapy alone in stage IIIB cervical squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2004;60:513–21.

    Article  CAS  PubMed  Google Scholar 

  32. Schmitt M, Wilhelm OG, Reuning U, Krüger A, Harbeck N, Lengyel E, et al. The urokinase plasminogen activation system as a novel target for toumour therapy. Fibrinolysis. 2000;14:114–32.

    Article  CAS  Google Scholar 

  33. Wang Y. The role and regulation of urokinase-type plasminogen activator receptor gene expression in cancer invasion and metastasis. Med Res Rev. 2001;21:146–70.

    Article  PubMed  Google Scholar 

  34. Andreasen PA, Egelund R, Petersen HH. The plasminogen activation system in tumor growth, invasion, and metastasis. Cell Mol Life Sci. 2000;57:25–40.

    Article  CAS  PubMed  Google Scholar 

  35. Horn LC, Pippig S, Raptis G, Fisher U, Kohler U, Hentschel B, et al. Clinical relevance of urokinase-type plasminogen activator and its inhibitor type 1 (PAI-1) in squamous cell carcinoma of the uterine cervix. Aust N Z J Obstet Gynaecol. 2002;42:383–6.

    Article  CAS  PubMed  Google Scholar 

  36. Shahrokh F, Shariat M, Monoski A, Andrews B, Wheeler TM, Lerner S. Association of plasma urokinase-type plasminogen activator and its receptor with clinical outcome in patients undergoing radical cystectomy for transitional cell carcinoma of the bladder. Urology. 2003;61:1053–8.

    Article  Google Scholar 

  37. Zemzoum I, Kates RE, Ross JS, Dettmar P, Dutta M, Henrichs C, et al. Invasion factors uPA/PAI-1 and HER2 status provide independent and complementary information on patient outcome in node-negative breast cancer. J Clin Oncol. 2003;21:1022–8.

    Article  CAS  PubMed  Google Scholar 

  38. Feldmann HJ, Seegenschmiedt MH, Molls M. Hyperthermia—its actual role in radiation oncology Part III: clinical rationale and results in deep seated tumors. Strahlenther Onkol. 1995;171:251–64.

    CAS  PubMed  Google Scholar 

  39. Eppink B, Krawczyk PM, Stap J, Kanaar R. Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies. Int J Hyperthermia. 2012;28(6):509–17.

    Article  CAS  PubMed  Google Scholar 

  40. Frey B, Weiss EM, Rubner Y, Wunderlich R, Ott OJ, et al. Old and new facts about hyperthermia-induced modulations of the immune system. Int J Hyperthermia. 2012;28(6):528–42.

    Article  CAS  PubMed  Google Scholar 

  41. Noordhuis MG, Eijsink JJ, Roossink F, De Graeff P, Pras E, Schuuring E, et al. Prognostic cell biological markers in cervical cancer patients primarily treated with (chemo) radiation: a systematic review. Int J Radiat Oncol Biol Phys. 2011;79(2):325–34.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Kansai Medical University, 10-5 Fumizono-cho, Moriguchi-City, Osaka, 570-8507, Japan

    Yoko Harima

Authors
  1. Yoko Harima
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yoko Harima .

Editor information

Editors and Affiliations

  1. Kokura Lab, Health and Medical Sciences, Kyoto Gakuen University, Kyoto, Kyoto, Japan

    Satoshi Kokura

  2. Department of Inflammation and Immunolog, Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Japan

    Toshikazu Yoshikawa

  3. Department of Radiation Oncology, Nara Medical University, Kashihara, Nara, Japan

    Takeo Ohnishi

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media Singapore

About this chapter

Cite this chapter

Harima, Y. (2016). Combination by Hyperthermia and Radiotherapy and/or Chemo-radiotherapy: Gyneology Cancer. In: Kokura, S., Yoshikawa, T., Ohnishi, T. (eds) Hyperthermic Oncology from Bench to Bedside. Springer, Singapore. https://doi.org/10.1007/978-981-10-0719-4_20

Download citation

  • DOI: https://doi.org/10.1007/978-981-10-0719-4_20

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-0717-0

  • Online ISBN: 978-981-10-0719-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation