Skip to main content

Future developments in renal transplantation

  • Chapter
Renal Failure- Who Cares?
  • 49 Accesses

Abstract

There have been some exciting advances in transplant research in the past 5 years which are now beginning to have an impact on clinical practice. In this chapter six topics have been selected which are likely to have a profound influence on the results of renal transplantation:

  • The centre effect,

  • Tissue typing,

  • Cytotoxic antibody testing,

  • Blood transfusion and allograft enhancement,

  • Immunosuppression and Immunological monitoring.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bodmer, W. F., Batchelor, J.R., Bodmer, J.G., Festenstein, H. and Morris, P.J. (eds.) (1978). Histocompatibility Testing, 1977 (Report of the Seventh International Histocompatibility Workshop and Conference, Oxford). ( Copenhagen: Munksgaard )

    Google Scholar 

  • Bord, J. F., Feurer, C., Gubler, H. U. and Stähelin, H. (1976). Biological effects of cyclosporin A: a new antilymphocytic agent. Agents Actions, 6, 468

    Article  Google Scholar 

  • Borleffs, J.C.C., Neuhaus, P., van Rood, J.J. and Balner, H., (1982). Platelet transfusions improve kidney allograft survival in rhesus monkeys without inducing cytotoxic antibodies. Lancet, 1, 1117

    Article  PubMed  CAS  Google Scholar 

  • Calne, R.Y., White, D.J.G., Thiru, S., Evans, D. B., McMaster, P., Dunn, D.C., Craddock, G. N., Pentlow, B. D. and Rolfes, K. (1978). Cyclosporin A in patients receiving renal allografts from cadaver donors. Lancet, 2, 1323

    Article  PubMed  CAS  Google Scholar 

  • Calne, R.Y., Rolfes, K., White, D.J.G., Thiru, S., Evans, D.B., McMaster, P., Dunn, D. C., Craddock, G.N., Henderson, R. G., Aziz, S. and Lewis, P. (1979). Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric-organs: 32 kidneys, two pancreases and two livers. Lancet, 2, 1033

    Article  PubMed  CAS  Google Scholar 

  • Caine, R. Y., Rolfes, K., White, D.J.G., Thiru, S., Evans, D. B., Henderson, R., Hamilton, D.L., Boone, N., McMaster, P., Gibby, O. and Williams, R. (1981). Cyclosporin A in clinical organ grafting. Transplant. Proc., 13, 349

    Google Scholar 

  • Dewar, P.J., Wilkinson, R., Elliott, R. W., Ward, M.K., Kerr, D. N. S., Kenward, D. H., Proud, G and Taylor, R. M. R. (1982). Superiority of B locus matching over other HLA matching in renal graft survival. Br. Med. J., 284, 779

    Article  CAS  Google Scholar 

  • Editorial (1978). Blood transfusions and renal transplantation. Lancet, 2, 193

    Google Scholar 

  • van Es, A. A. and Balner, H. (1979). Effect of pre-transplant transfusions on kidney allograft survival. Transplant. Proc., 11, 127

    PubMed  Google Scholar 

  • Festenstein, H., Sachs, J.A., Butterfield, K., Yeatman, N. and Holmes, J. (1981). Collaborative scheme for tissue typing and matching in renal transplantation. XI. Role of HLA-A, B, DR and D matching and other factors on 899 cadaver kidney grafts. Transplant. Proc., 13, 934

    PubMed  CAS  Google Scholar 

  • Häyry, P. and von Willebrand, E. (1978). Fine-needle aspiration cytology in the prediction and diagnosis of acute rejection episodes in man. Proc. Eur. Dial. Transplant Assoc., 15, 335

    PubMed  Google Scholar 

  • Homan, W.P., French, M.E., Millard, P. R. and Morris, P.J. (1981). A study of eleven drug regimens using cyclosporin A to suppress renal allograft rejection in the dog. Transplant. Proc., 13, 397

    PubMed  CAS  Google Scholar 

  • Jacobs, C., Broyer, M., Brunner, F.P., Brynger, H., Donckerwolcke, R.A., Kramer, P., Selwood, N. H., Wing, A. J. and Blake, P. H. (1981). Combined report on regular dialysis and transplantation in Europe, XI, 1980. Proc. Eur. Dial. Transplant Assoc., 18, 4

    PubMed  CAS  Google Scholar 

  • Keown, P. A. and Descamps, B. (1979). Improved renal allograft survival after blood transfusion: a non-specific erythrocyte-mediated immuno-regulatory process? Lancet, 1, 20

    Article  PubMed  CAS  Google Scholar 

  • Kostakis, A.J., White, D.J.G. and Calne, R.Y. (1977). Prolongation of rat heart allograft survival by cyclosporin A. IRCS Med. Sci. Library Compendium, 5, 280

    CAS  Google Scholar 

  • McGeown, M. G., Kennedy, J. A., Loughridge, W. G. G., Douglas, J., Alexander, J.A., Clarke, S. D., McEvoy, J. and Hewitt, J.C. (1977). One hundred transplants in the Belfast City Hospital. Lancet, 2, 648

    Article  PubMed  CAS  Google Scholar 

  • Morris, P. J. and Ting, A. (1981). The cross-match in renal transplantation. Tissue Antigens, 17, 75

    Article  PubMed  CAS  Google Scholar 

  • Opelz, G., Sengar, D.P.S., Mickey, M. R. and Terasaki, P. I. (1973). Effect of blood transfusions on subsequent kidney transplants. Transplants. Proc., 5, 253

    CAS  Google Scholar 

  • Opelz, G. and Terasaki, P. I. (1980). Dominant effect of transfusions on kidney graft survival. Transplantation, 29, 153

    Article  PubMed  CAS  Google Scholar 

  • Opelz, G. and Terasaki, P. I. (1982). International study of histocompatibility in renal transplantation. Transplantation, 33, 87

    Article  PubMed  CAS  Google Scholar 

  • Payne, R., Tripp, M., Weigle, J., Bodmer, W. F. and Bodmer, J.G. (1964). New leukocyte iso-antigen system in man. Cold Spring Harbor Symp. Quant. Biol., 29, 285

    Article  PubMed  CAS  Google Scholar 

  • van Rood, J. J., Balner, H. and Morris, P. J., (1978). Blood transfusion and transplantation. Transplantation, 26, 275

    Article  PubMed  Google Scholar 

  • Salaman, J. R. (1981). Pharmalogical immunosuppressive agents. In Salaman, J. R. (ed.). Immunosuppressive Therapy. pp. 3–18. ( Lancaster: MTP Press )

    Google Scholar 

  • Snell, G. D. (1948). Methods for the study of histocompatibility genes. J. Genet., 49, 87

    Article  PubMed  CAS  Google Scholar 

  • Ting, A. and Morris, P. J. (1977). Renal transplantation and B-cell cross-matches with autoantibodies and alloantibodies. Lancet, 2, 1095

    Article  PubMed  CAS  Google Scholar 

  • Ting, A and Morris, P. J. (1978). Reactivity of autolymphocytotoxic antibodies from dialysis patients with lymphocytes from chronic lymphocytic leukemia (CLL) patients. Transplantation, 25, 31

    Article  PubMed  CAS  Google Scholar 

  • UK Transplant: Annual Report (1978–1979) UK Transplant Service, Southmead Road, Bristol, UK

    Google Scholar 

  • Williams, A. F. (1979). Monoclonal antibodies in transplantation research. Transplantation, 27, 152

    Article  PubMed  CAS  Google Scholar 

  • Wood, R. F. M., Bolton, E.M., Thompson, J.F. and Morris, P.J. (1982). Monoclonal antibodies and fine needle aspiration cytology in detecting renal allograft rejection. Lancet, 2, 278

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1983 MTP Press Limited

About this chapter

Cite this chapter

Wood, R.F.M. (1983). Future developments in renal transplantation. In: Parsons, F.M., Ogg, C.S. (eds) Renal Failure- Who Cares?. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-8077-1_13

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-8077-1_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-8079-5

  • Online ISBN: 978-94-011-8077-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics