Abstract
Many individuals marvel at liver regeneration as an example of coordinated cell growth. About this there is no argument — within a matter of days, liver cells can completely recover from injury or resection by restoring their original mass. Equally fascinating, however, is that, during this same interval, epithelia, endothelia and mesenchyme manage to rearrange themselves into a very complex lobular configuration. Restructuring of the hepatic lobule is not automatically associated with liver cell growth: indeed, in chronic injury states, attempts at cellular repair are often disorganized, leading to nodule formation and cirrhosis. The fact that reorganization can be separated to some extent from growth in the regenerating liver implies that a unique set of signals controls the restructuring process. One likely candidate for this role is the hepatic extracellular matrix.
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References
Alcorn, J.A., Feitelberg, S.P. and Brenner, D.A. (1990) Transient induction of c-jun during hepatic regeneration. Hepatology, 11, 909–915.
Angel, P., Imagawa, M., Chiu, R. et al. (1987) Phorbol ester-inducible genes contain acommon cis element recognized by a TPA-modulated trans-acting factor. Cell, 49, 729–739.
Anilkumar, N. and Sudhakaran, P.R. (1993) Isolation and characterization of laminin binding protein from regeneration rat liver plasma membrane. Biochemistry and Molecular Biology International, 31, 201–209.
Arthur, M.J. (1990) Matrix degradation in the liver. Seminars in Liver Disease, 10, 47–55.
Barioz, C.M., Sengel, P. and Grimaud, J.A. (1988) Immunolocalization of matricial components during the early stages of chick embryonic liver development. Biological Strictures and Morphogenesis, 1, 3–14.
Bissell, D.M., Arenson, D.M., Maher, J.J. and Roll, F.J. (1987) Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver. Journal of Clinical Investigation, 79, 801–812.
Bucher, N.L., Robinson, G.S. and Farmer, S.R. (1990) Effects of extracellular matrix on hepatocyte growth and gene expression: implications for hepatic regeneration and the repair of liver injury. Seminars in Liver Disease, 10, 11–19.
Burgeson, R.E., Chiquet, M., Deutzmann, R. et al. (1994) A new nomenclature for the laminins. Matrix Biology, 14, 209–211.
Caputi, M., Melo, C.A. and Baralle, F.E. (1995) Regulation of fibronectin expression in rat regenerating liver. Nucleic Acids Research, 23, 238–243.
Carlsson, R., Engvall, E., Freeman, A. and Ruoslahti, E. (1981) Laminin and fibronectin in cell adhesion: enhanced adhesion of cells from regenerating liver to laminin. Proceedings of the National Academy of Sciences USA, 78, 2403–2406.
Clement, B., Guguen-Guillouzo, C., Campion, J.P. et al. (1984) Long-term co-cultures of adult human hepatocytes with rat liver epithelial cells: modulation of albumin secretion and accumulation of extracellular material. Hepatology, 4, 373–380.
Clement, B., Rescan, P.Y., Baffet, G. et al. (1988) Hepatocytes may produce laminin in fibrotic liver and in primary culture. Hepatology, 8, 794–803.
Diehl, A.M., Yin, M., Fleckenstein, J. et al. (1994) Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. American Journal of Physiology, 267, G552–G561.
Friedman, S.L., Roll, F.J., Boyles, J. et al. (1989) Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. Journal of Biological Chemistry, 264, 10756–10762.
Gardner, M.J., Fletcher, K., Pogson, C.I. and Strain, A.J. (1996) The mitogenic response to EGF of rat hepatocytes cultured on laminin-rich gels (EHS) is blocked downstream of receptor tyrosine phosphorylation. Biochemical and Biophysical Research Communications, 228, 238–245.
Gimenez, A., Hostench, J., Stamatoglou, S.C. and Enrich, C (1995) Differential expression of A and B laminin chains during rat liver regeneration. Hepatology, 22, 1259–1262.
Goulet, F., Normand, C. and Morin, O. (1988) Cellular interactions promote tissue-specific function, biomatrix deposition and junctional communication of primary cultured hepatocytes. Hepatology, 8, 1010–1018.
Grant, D.S., Kinsella, J.L., Fridman, R. et al. (1992) Interaction of endothelial cells with a laminin A chain peptide (SIKVAV) in vitro and induction of angiogenic behavior in vivo. Journal of Cellular Physiology, 153, 614–62
Griffiths, M.R., Keir, S. and Burt, A.D. (1991) Basement membrane proteins in the space of Disse: a reappraisal. Journal of Clinical Pathology, 44, 646–648.
Griffiths, M.R., Shepherd, M., Ferrier, R. et al. (1992) Light microscopic and ultrastructural distribution of type VI collagen in human liver: alterations in chronic biliary disease. Histopathology, 21, 335–344.
Herbst, H., Heinrichs, O., Schuppan, D. et al. (1991) Temporal and spatial patterns of transin/ stromelysin RNA expression following toxic injury in rat liver. Virchows Archiv B. Cell Pathology and Molecular Pathology, 60, 295–300.
Jakowlew, S.B., Mead, J.E., Danielpour, D. et al. (1991) Transforming growth factor-beta (TGF-beta) isoforms in rat liver regeneration: messenger RNA expression and activation of latent TGF-beta. Cell Regulation, 2, 535–548.
Kato, S., Otsu, K., Ohtake, K. et al. (1992) Concurrent changes in sinusoidal expression of laminin and affinity of hepatocytes to laminin during rat liver regeneration. Experimental Cell Research, 198, 59–68.
Kato, S., Ishii, T., Hara, H. et al. (1994) Hepatocyte growth factor immobilized onto culture substrates through heparin and matrigel enhances DNA synthesis in primary rat hepatocytes. Experimental Cell Research, 211, 53–58.
Liu, M.L., Mars, W.M., Zarnegar, R. and Michalopoulos, G.K. (1994) Collagenase pretreatment and the mitogenic effects of hepatocyte growth factor and transforming growth factor-alpha in adult rat liver. Hepatology, 19, 1521–1527.
Loreal, O., Levavasseur, F., Rescan, P.Y. et al. (1991) Differential expression of laminin chains in hepatic lipocytes. FEBS Letters, 290, 9–12.
Loreal, O., Levavasseur, F., Fromaget, C. et al. (1993) Cooperation of Ito cells and hepatocytes in the deposition of an extracellular matrix in vitro. American Journal of Pathology, 143, 538–544.
Maher, J.J. and McGuire, R.F. (1990) Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo. Journal of Clinical Investigation, 86, 1641–1648.
Maher, J.J. and Bissell, D.M. (1993) Cell-matrix interactions in liver. Seminars in Cell Biology, 4, 189–201.
Maher, J.J. and Tzagarakis, C. (1994) Partial cloning of the M subunit of laminin from adult rat lipocytes: expression of the M subunit by cells isolated from normal and injured liver. Hepatology, 19, 764–770.
Maher, J.J., Friedman, S.L., Roll, F.J. and Bissell, D.M. (1988) Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture. Gastroenterology, 94, 1053–1062.
Martinez-Hernandez, A. (1984) The hepatic extracellular matrix. I. Electron immunohistochemical studies in normal rat liver. Laboratory Investigation, 51, 57–74.
Martinez-Hernandez, A. and Amenta, P.S. (1993) The hepatic extracellular matrix. II. Ontogenesis, regeneration and cirrhosis. Virchows Archiv A. Pathological Anatomy and Histopathology, 423, 77–84.
Martinez-Hernandez, A., Delgado, F.M. and Amenta, P.S. (1991) The extracellular matrix in hepatic regeneration. Localization of collagen types I, III, IV, laminin, and fibronectin. 64, 157–166. (An erratum appears in Laboratory Investigation, 1991, 65 (2), 257).
Masumoto, A. and Yamamoto, N. (1993) Stimulation of DNA synthesis in hepatocytes by hepatocyte growth factor bound to extracellular matrix. Biochemical and Biophysical Research Communications, 191, 1218–1223.
Matrisian, L.M., Leroy, P., Ruhlmann, C. et al. (1986) Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts. Molecular and Cellular Biology, 6, 1679–1686.
Nakatsukasa, H., Evarts, R.P., Hsia, C.C. and Thorgeirsson, S.S. (1990) Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver. Laboratory Investigation, 63, 171–180.
Nicosia, R.F., Bonanno, E., Smith, M. and Yurchenco, P. (1994) Modulation of angiogenesis in vitro by laminin-entactin complex. Developmental Biology, 164, 197–206.
Odenthal, M., Neubauer, K., Meyer zum Buschenfelde, K.H. and Ramadori, G. (1993) Localization and mRNA steady-state level of cellular fibronectin in rat liver undergoing a CC14-induced acute damage or fibrosis. Biochimica et Biophysica Acta, 1181, 266–272.
Paralkar, V.M., Vukicevic, S. and Reddi, A.H. (1991) Transforming growth factor beta type 1 binds to collagen IV of basement membrane matrix: implications for development. Developmental Biology, 143, 303–308.
Pujades, C., Forsberg, E., Enrich, C. and Johansson, S. (1992) Changes in cell surface expression of fibronectin and fibronectin receptor during liver regeneration. Journal of Cell Science, 102, 815–820.
Reid, L.M., Fiorino, A.S., Sigal, S.H. et al. (1992) Extracellular matrix gradients in the space of Disse: relevance to liver biology. Hepatology, 15, 1198–1203 (editorial).
Reif, S., Terranova, V.P., El-Bendary, M. et al. (1990) Modulation of extracellular matrix proteins in rat liver during development. Hepatology, 12, 519–525.
Reif, S., Sykes, D., Rossi, T. and Weiser, M.M. (1992) Changes in transcripts of basement components during rat liver development: increase in laminin messenger RNAs in the neonatal period. Hepatology, 15, 310–315.
Rescan, P.Y., Clement, B., Crimaud, J.A. et al. (1989) Participation of hepatocytes in the production of basement membrane components in human and rat liver during the perinatal period. Cell Differentiation and Development, 26, 131–144.
Rescan, P.Y., Loreal, O., Hassell, J.R. et al. (1993) Distribution and origin of the basement membrane component perlecan in rat liver and primary hepatocyte culture. American Journal of Pathology, 142, 199–208.
Schnaper, H.W., Kleinman, H.K. and Grant, D.S. (1993) Role of laminin in endothelial cell recognition and differentiation. Kidney International, 43, 20–25.
Schuppan, D. (1990) Structure of the extracellular matrix in normal and fibrotic liver: collagens and glycoproteins. Seminars in Liver Disease, 10, 1–10.
Shakado, S., Sakisaka, S., Noguchi, K. et al. (1995) Effects of extracellular matrices on tube formation of cultured rat hepatic sinusoidal endothelial cells. Hepatology, 22, 969–973.
Tryggvason, K. (1993) The laminin family. Current Opinion in Cell Biology, 5, 877–882.
Van Eyken, P., Geerts, A., De Bleser, P. et al. (1992) Localization and cellular source of the extracellular matrix protein tenascin in normal and fibrotic rat liver. Hepatology, 15, 909–916.
Vukicevic, S., Kleinman, H.K., Luyten, F.P. et al. (1992) Identification of multiple active growth factors in basement membrane Matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components. Experimental Cell Research, 202, 1–8.
Wan, Y.J., Wu, T.C., Chung, A.E. and Damjanov, I. (1984) Monoclonal antibodies to laminin reveal the heterogeneity of basement membranes in the developing and adult mouse tissues. Journal of Cell Biology, 98, 971–979.
Westwick, J.K., Weitzel, C., Leffert, H.L. and Brenner, D.A, (1995) Activation of Jun kinase is an early event in hepatic regeneration. Journal of Clinical Investigation, 95, 803–810.
Wewer, U.M. and Engvall, E. (1994) Laminins. Methods in Enzymology, 245, 85–104.
Wewer, U.M., Engvall, E., Paulsson, M. et al. (1992) Laminin A, B1, B2, S and M subunits in the postnatal rat liver development and after partial hepatectomy. Laboratory Investigation, 66, 378–389.
Yamamoto, H., Murawaki, Y. and Kawasaki, H. (1995) Hepatic collagen synthesis and degradation during liver regeneration after partial hepatectomy. Hepatology, 21, 155–161.
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Maher, J.J. (1998). The extracellular matrix in liver regeneration. In: Strain, A., Diehl, A.M. (eds) Liver Growth and Repair. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4932-7_17
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DOI: https://doi.org/10.1007/978-94-011-4932-7_17
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