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Renal bone disease

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Book cover Biopsy of Bone in Internal Medicine: An Atlas and Sourcebook

Part of the book series: Current Histopathology ((CUHI,volume 21))

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Abstract

The term ‘renal bone disease’ or ‘renal osteodystrophy’ is used to describe osseous disorders occurring in patients with renal disease21,33,43,49,53,71. Abnormalities of bone are seen mainly in patients suffering from chronic renal failure (impaired glomerular filtration rate, GFR). Variants of metabolic bone disease may also occur in patients with a normal GFR, but with renal tubular acidosis, nephrotic syndrome, renal stone diseases and oxalosis. A wide spectrum of factors influences the skeleton in renal disorders: the type of renal disease, the degree of uraemia, the severity of secondary hyperparathyroidism, changes in vitamin D metabolism, accumulation of toxic products (e.g. aluminium, fluorine, iron)11,51,68,70, the type and duration of dialysis therapy and of drugs, particularly corticosteroids5,21,25,26,37,38,50. Patients with renal disease are also subject to the same conditions that affect the skeleton in normal individuals: sex, age, activity, endocrine disturbances, ethanol intake, immobilization, diabetes mellitus5 and so forth. For example, renal complications may occur in B-cell dyscrasias due to deposition of monoclonal immunoglobulins in the kidneys34.

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Authors and Affiliations

  1. Department of Internal Medicine III, Unit for Bone and Bone Marrow Diagnosis, Germany

    R. Bartl

  2. Klinikum Großhadern, University of Munich, Germany

    R. Bartl

  3. Department of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel

    B. Frisch

  4. Sackler School of Medicine, Tel-Aviv University, Israel

    B. Frisch

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© 1993 R. Bartl and B. Frisch

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Bartl, R., Frisch, B. (1993). Renal bone disease. In: Biopsy of Bone in Internal Medicine: An Atlas and Sourcebook. Current Histopathology, vol 21. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2222-1_14

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  • DOI: https://doi.org/10.1007/978-94-011-2222-1_14

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