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Osteosclerosis

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Biopsy of Bone in Internal Medicine: An Atlas and Sourcebook

Part of the book series: Current Histopathology ((CUHI,volume 21))

Abstract

Osteosclerosis is characterized by an increase in skeletal mass (hyperostosis), usually involving both cortical and cancellous bone. In spite of the increase in density the affected bones are more fragile. Osteosclerosis is caused by increased bone formation, reduced bone resorption or both, and may be either inherited or acquired13,40. The osteoscleroses may be local, multifocal or generalized, and result from a variety of metabolic, inflammatory, toxic or neoplastic disorders in addition to the congenital forms1,3,9. The commoner syndromes which present with increased bone density are listed in Table 10.1. Those not related to metabolic and hereditary disorders will be discussed in the appropriate chapters. Increments in bone mass are manifest radiologically as increased osseous density, with variable alterations of the architecture of the bones involved6,27.

Table 10.1 Main causes of osteosclerosis
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Authors and Affiliations

  1. Department of Internal Medicine III, Unit for Bone and Bone Marrow Diagnosis, Germany

    R. Bartl

  2. Klinikum Großhadern, University of Munich, Germany

    R. Bartl

  3. Department of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel

    B. Frisch

  4. Sackler School of Medicine, Tel-Aviv University, Israel

    B. Frisch

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© 1993 R. Bartl and B. Frisch

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Bartl, R., Frisch, B. (1993). Osteosclerosis. In: Biopsy of Bone in Internal Medicine: An Atlas and Sourcebook. Current Histopathology, vol 21. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2222-1_11

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  • DOI: https://doi.org/10.1007/978-94-011-2222-1_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4985-6

  • Online ISBN: 978-94-011-2222-1

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