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Antibodies in the study of multiple drug resistance

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Book cover Multiple Drug Resistance in Cancer

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Abstract

Multidrug resistance (MDR) is a major problem in cancer chemotherapy. As P-glycoprotein is the key molecule in MDR, many investigators have constructed anti-P-glycoprotein monoclonal antibodies (MAbs). Those antibodies, including MRK16 and C219, were used for elucidation of the mechanism of MDR and for overcoming of MDR. This article describes the characterization of the antibodies against the P-glycoprotein and other proteins of multidrug-resistant tumor cells, and discusses the therapeutic implication of the antibodies.

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Abbreviations

ADCC:

antibody-dependent cell-mediated cytotoxicity

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Authors and Affiliations

  1. Pharmacology Division, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo, 104, Japan

    Yuji Heike

  2. Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, 113, Japan

    Takashi Tsuruo

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  1. Yuji Heike
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  2. Takashi Tsuruo
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Editors and Affiliations

  1. National Cell & Tissue Culture Center/Bioresearch Ireland, Dublin City University, Glasnevin, Dublin, Ireland

    Martin Clynes

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© 1994 Springer Science+Business Media Dordrecht

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Heike, Y., Tsuruo, T. (1994). Antibodies in the study of multiple drug resistance. In: Clynes, M. (eds) Multiple Drug Resistance in Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0826-3_4

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  • DOI: https://doi.org/10.1007/978-94-011-0826-3_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4355-7

  • Online ISBN: 978-94-011-0826-3

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