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A Toxicologist’s View of Immunotoxicology

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Immunotoxicology

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 16))

Abstract

Whenever awareness about a new area of concern in toxicology reaches a critical level, national and international public health authorities request the immediate development of testing procedures with which large numbers of established and new chemicals can be evaluated. Previous experience in the areas of teratogenicity, carcinogenicity, mutagenicity and others has shown that toxicologists respond enthusiastically to such demands. Unfortunately, in their eagerness to test as many chemicals as possible, scientists often do not spend sufficient time studying the theoretical basis and medical relevance of their experimental models. Moreover, classical concepts of toxicology, e.g. the compulsory use of excessively high doses, are uncritically applied in the newly developed tests.

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References

  • Andersen, K.E., 1983. Predictive skin and mucosa testing methods. In Allergic Responses and Hypersensitivities Induced by Chemicals, Health Aspects of Chemical Safety, Interim Document 12, World Health Organization, Regional Office for Europe, Copenhagen, pp 243–275.

    Google Scholar 

  • Balazs, T. & Robinson, C.J.G., 1983. Procainamide/induced antinuclear antibodpes in beagle dogs. Toxicol. Appi. Pharmacol. 71, 299–302.

    Article  CAS  Google Scholar 

  • Bickel, G., 1960 Allergie et myocarde. Schweiz. med. Wchschr. 90, 912–921.

    Google Scholar 

  • D’Agnolo G., 1983 The control of drugs obtained by recombinant DNA and other biotechnologies. In current Problems in Drug Toxicology. Eds G. Zbinden, F. Cohadon, J.Y. Detaille & G. Mazue. John Libbey Eurotext: Paris & London, pp 241–247.

    Google Scholar 

  • Falchetti, R., Silvestri, S., Battaglia, A., & Caprino, L., 1983. Toxicological evaluation of immunomodulating drugs. In Current Problems in Drug Toxcology. Eds. G. Zbinden, F. Cohadon, J.Y. Detaille & G. Mazue. John Libbey Eurotext: Paris & London, pp 248–263.

    Google Scholar 

  • Healy, D.L., Hodgen, G.D., Schulte, H.M., Chrousos, G.P., Loriaux, D.L., Hall, N.R. & Goldstein, A.L., 1983. The thymus-adrenal connection: thymosin has coricotropin-releasing activity in primates. Science 222, 1353–1355.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, I.S., 1982. Authenticity and purity of human insulin (recombinant DNA). Diabetic Care, 5, Suppl. 2, 4–12.

    Google Scholar 

  • Koller, L.D. & Vos, J.G., 1981 Immunologic effects of metals. In Immunologic Considerations in Toxicology, Vol. 1. Ed. R.P. Sharma. CRC Press, Inc.: Boca Raton FL, pp 67–78.

    Google Scholar 

  • Levine, S., Gibson, J.P., & Megel, H., 1974. Selective depletion of thyumus dependent areas in lymphoid tissue by tilorone. Proc. Soc. Exp. Biol. Med. 146, 245–248.

    PubMed  CAS  Google Scholar 

  • Maurer, T. 1983. Contact and photocontact allergens. A manual of predictive test methods. Marcel Dekker Inc. New York, Basel.

    Google Scholar 

  • Morin, A. & Chedid, L., 1983. Apport de 1’immunopharmacologie dans 2’evaluation toxicologique des immunomodulants. In Current Problems in Drug Toxicology. G. Zbinden, F. Cohadon, J.Y. Detaille & G. Mazue, Eds. John Libbey Eurotext: Paris & London, pp 294–302.

    Google Scholar 

  • Ovtcharov, R., Guentcheva, G., & Michailova, S., 1980. Some approaches to experimental testing of drugs for immunotoxicity. Arch. Toxicol., Suppl. 4,, 120 /131.

    CAS  Google Scholar 

  • Petricciani, J.C., 1983. An overview of safety and regulatory aspects of the new biotechnology. Regulatory Toxicol. Pharmacol. 3, 428–433.

    Article  CAS  Google Scholar 

  • Renoux G., 1983. Les exigences de l’evaluation immunopharma-cologique d’un medicament. In Current Problems in Drug Toxicology. G. Zbinden, F. Cohadon, J.Y. Detaillé & G. Mazue, eds. John Libbey Eurotext: Paris & London, pp 310–314.

    Google Scholar 

  • Ruiz-Arguelles, A., Seroogy, K.B., & Ritts, R.R. Jr. 1982. In vitro effect of cimetidine on human cell-mediated cytotoxicity. 1. Inhibition of natural killer cell activity. Cellular Immunol. 62, 1–12.

    Google Scholar 

  • Sharma, R.P. (a), 1981. Tissue and cell injury in immune mechanisms. In Immunologic Considerations in Toxicology, Vol. 1, R.P. Sharma ed., CRC Press, Inc. Boca Raton, FL, pp 37–44.

    Google Scholar 

  • Sharma, R.P. (b), 1981. Effects of Tetrachlorodibenzo-p-dioxin (TCDD) on immunologic systems. In Immunologic considerations in Toxicology, Vol. 1, R.P. Sharma, ed., CRC Press Inc. Boca Raton FL, pp 89–102.

    Google Scholar 

  • Street, J.S.C., 1981. Pesticides and the immune system. In Immunologic Considerations in Toxicology, Vol. 1, R.P. Sharma, ed., CRC Press, Inc. Boca Raton FL, pp 45–66.

    Google Scholar 

  • Vos, J.G., 1977. Immmune supression as related to toxicology. CRC Crit. Rev. Toxicol. 5, 67–101.

    Article  PubMed  CAS  Google Scholar 

  • Vos, J.G., Moore, J.A., & Zinkl, J.G., 1973. Effect of 2, 2, 7, 8-tetrachlorodibenzo-p-dioxin on the immune system of laboratory Environmental Health Perspectives, Experimental Issue 5, 149–162.

    CAS  Google Scholar 

  • Zbinden, G. & Emchp, E., 1972. Effect of tilorone HC1, an oral interferon inducer, on leukopoiesis in rats. Acta Haematol. 47, 49–58.

    Article  CAS  Google Scholar 

  • Zbinden, G., Eisner, J., & Boelsterli U., 1984. Toxicological Screening, Regulatory Toxicol. Phatmacol. In press.

    Google Scholar 

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© 1987 ECSC, EEC, EAEC, Brussels-Luxembourg and WHO, Geneva

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Zbinden, L.C. (1987). A Toxicologist’s View of Immunotoxicology. In: Berlin, A., Dean, J., Draper, M.H., Smith, E.M.B., Spreafico, F. (eds) Immunotoxicology. Developments in Hematology and Immunology, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4307-0_1

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  • DOI: https://doi.org/10.1007/978-94-009-4307-0_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8414-7

  • Online ISBN: 978-94-009-4307-0

  • eBook Packages: Springer Book Archive

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