Abstract
Macroscopically, hemangiopericytoma (HPC) and meningioma are similar. However, treatment strategies for these tumors sometimes differ because of differences in their clinical behavior and structure, principally their vascularity.
HPC must be totally resected at initial surgery, which sometimes requires preoperative embolization, and close radiographic follow-up is mandatory for detection of local recurrence or metastasis. In the case of residual tumors, adjuvant radiotherapy including conventional radiotherapy, stereotactic radiosurgery, and stereotactic radiotherapy should be deployed. Repeat surgery or salvage radiotherapy is effective. Although chemotherapy has not shown definitive efficacy until date, novel approaches for systemic metastasis that cannot be controlled by present modalities are expected.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abrahams JM, Forman MS, Lavi E, Goldberg H, Flamm ES (1999) Hemangiopericytoma of the third ventricle. Case report. J Neurosurg 90(2):359–362
Bailey P, Cushing H, Eisenhardt L (1928) Angioblastic meningiomas. Arch Pathol Lab Med 6:953–990
Barba I, Moreno A, Martinez-Perez I, Tate AR, Cabanas ME, Baquero M, Capdevila A, Arus C (2001) Magnetic resonance spectroscopy of brain hemangiopericytomas: high myoinositol concentrations and discrimination from meningiomas. J Neurosurg 94(1):55–60
Bastin KT, Mehta MP (1992) Meningeal hemangiopericytoma: defining the role for radiation therapy. J Neurooncol 14(3):277–287
Begg CF, Garret R (1954) Hemangiopericytoma occurring in the meninges: case report. Cancer 7(3):602–606
Chamberlain MC, Glantz MJ (2008) Sequential salvage chemotherapy for recurrent intracranial hemangiopericytoma. Neurosurgery 63(4):720–726, author reply 726–727
Chiechi MV, Smirniotopoulos JG, Mena H (1996) Intracranial hemangiopericytomas: MR and CT features. AJNR Am J Neuroradiol 17(7):1365–1371
Combs SE, Thilmann C, Debus J, Schulz-Ertner D (2005) Precision radiotherapy for hemangiopericytomas of the central nervous system. Cancer 104(11):2457–2465
Cornelius JF, Saint-Maurice JP, Bresson D, George B, Houdart E (2007) Hemorrhage after particle embolization of hemangioblastomas: comparison of outcomes in spinal and cerebellar lesions. J Neurosurg 106(6):994–998
Cushing H, Eisenhardt L (1938) Meningiomas; their classification, regional behavior, life history, and surgical end results. Charles C. Thomas, Springfield
Delgado M, Perez-Ruiz E, Alcalde J, Perez D, Villatoro R, Rueda A (2011) Anti-angiogenic treatment (sunitinib) for disseminated malignant haemangiopericytoma: a case study and review of the literature. Case Rep Oncol 4(1):55–59
Dietzmann K, von Bossanyi P, Warich-Kirches M, Kirches E, Synowitz HJ, Firsching R (1997) Immunohistochemical detection of vascular growth factors in angiomatous and atypical meningiomas, as well as hemangiopericytomas. Pathol Res Pract 193(7):503–510
Dufour H, Metellus P, Fuentes S, Murracciole X, Regis J, Figarella-Branger D, Grisoli F (2001) Meningeal hemangiopericytoma: a retrospective study of 21 patients with special review of postoperative external radiotherapy. Neurosurgery 48(4):756–762; discussion 762–753
Ecker RD, Marsh WR, Pollock BE, Kurtkaya-Yapicier O, McClelland R, Scheithauer BW, Buckner JC (2003) Hemangiopericytoma in the central nervous system: treatment, pathological features, and long-term follow up in 38 patients. J Neurosurg 98(6):1182–1187
Hatva E, Bohling T, Jaaskelainen J, Persico MG, Haltia M, Alitalo K (1996) Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas. Am J Pathol 148(3):763–775
Juco J, Horvath E, Smyth H, Rotondo F, Kovacs K (2007) Hemangiopericytoma of the sella mimicking pituitary adenoma: case report and review of the literature. Clin Neuropathol 26(6):288–293
Kano H, Niranjan A, Kondziolka D, Flickinger JC, Lunsford LD (2008) Adjuvant stereotactic radiosurgery after resection of intracranial hemangiopericytomas. Int J Radiat Oncol Biol Phys 72(5):1333–1339
Kirn DH, Kramer A (1996) Long-term freedom from disease progression with interferon alfa therapy in two patients with malignant hemangiopericytoma. J Natl Cancer Inst 88(11):764–765
Kleihues P, Burger PC, Scheithauer BW (1993) The new WHO classification of brain tumours. Brain Pathol 3:255–268
Lamar Z, Lesser GJ (2011) Management of meningeal neoplasms: meningiomas and hemangiopericytomas. Curr Treat Options Oncol 12(3):230–239
Marc JA, Takei Y, Schechter MM, Hoffman JC (1975) Intracranial hemangiopericytomas. Angiography, pathology and differential diagnosis. Am J Roentgenol Radium Ther Nucl Med 125(4):823–832
Middleton LP, Duray PH, Merino MJ (1998) The histological spectrum of hemangiopericytoma: application of immunohistochemical analysis including proliferative markers to facilitate diagnosis and predict prognosis. Hum Pathol 29(6):636–640
Muto J, Kawase T, Yoshida K (2010) Meckel’s cave tumors: relation to the meninges and minimally invasive approaches for surgery: anatomic and clinical studies. Neurosurgery 67(3):291–298; discussions 298–299
Olson C, Yen CP, Schlesinger D, Sheehan J (2010) Radiosurgery for intracranial hemangiopericytomas: outcomes after initial and repeat Gamma Knife surgery. J Neurosurg 112(1):133–139
Park MS, Ravi V, Araujo DM (2010) Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. Curr Opin Oncol 22(4):351–355
Peters KB, McLendon R, Morse MA, Vredenburgh JJ (2010) Treatment of recurrent intracranial hemangiopericytoma with SRC-related tyrosine kinase targeted therapy: a case report. Case Rep Oncol 3(1):93–97
Rajaram V, Brat DJ, Perry A (2004) Anaplastic meningioma versus meningeal hemangiopericytoma: immunohistochemical and genetic markers. Hum Pathol 35(11):1413–1418
Rutkowski MJ, Sughrue ME, Kane AJ, Aranda D, Mills SA, Barani IJ, Parsa AT (2010) Predictors of mortality following treatment of intracranial hemangiopericytoma. J Neurosurg 113(2):333–339
Rutkowski MJ, Jian BJ, Bloch O, Chen C, Sughrue ME, Tihan T, Barani IJ, Berger MS, McDermott MW, Parsa AT (2012) Intracranial hemangiopericytoma: clinical experience and treatment considerations in a modern series of 40 adult patients. Cancer 118(6):1628–1636
Schiariti M, Goetz P, El-Maghraby H, Tailor J, Kitchen N (2011) Hemangiopericytoma: long-term outcome revisited. Clinical article. J Neurosurg 114(3):747–755
Sibtain NA, Butt S, Connor SE (2007) Imaging features of central nervous system haemangiopericytomas. Eur Radiol 17(7):1685–1693
Soyuer S, Chang EL, Selek U, McCutcheon IE, Maor MH (2004) Intracranial meningeal hemangiopericytoma: the role of radiotherapy: report of 29 cases and review of the literature. Cancer 100(7):1491–1497
Stone JL, Cybulski GR, Rhee HL, Bailey OT (1983) Excision of a large pineal region hemangiopericytoma (angioblastic meningioma, hemangiopericytoma type). Surg Neurol 19(2):181–189
Stout AP, Murray MR (1942) Hemangiopericytoma: a vascular tumor featuring Zimmermann’s pericytes. Ann Surg 116(1):26–33
Veeravagu A, Jiang B, Patil CG, Lee M, Soltys SG, Gibbs IC, Chang SD (2011) CyberKnife stereotactic radiosurgery for recurrent, metastatic, and residual hemangiopericytomas. J Hematol Oncol 4:26
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Akiyama, T., Yoshida, K., Horiguchi, T., Kawase, T. (2014). Management of Hemangiopericytoma. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 13. Tumors of the Central Nervous System, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7602-9_4
Download citation
DOI: https://doi.org/10.1007/978-94-007-7602-9_4
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-7601-2
Online ISBN: 978-94-007-7602-9
eBook Packages: MedicineMedicine (R0)