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Midkine: From Embryogenesis to Pathogenesis and Therapy pp 89–101Cite as

Midkine in Inflammation and Inflammatory Diseases

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Abstract

Midkine (MK) and pleotrophin (PTN) are members of a family of heparin-binding growth factors that promotes the proliferation, differentiation, survival, adhesion, migration, and other activities of responding cells, they have become promising molecular targets for the treatment of diseases including malignancy and immune mediated inflammatory diseases. MK is involved in the regulation of organ development and the etiology of many diseases. This chapter focuses on both cell protective and cytokine like effects of MK in different inflammatory conditions at the cellular/systemic levels.

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Author information

Authors and Affiliations

  1. Pathophysiology Department, Ankara University, Morfoloji Binasi, 06100, Sihhiye, Ankara, Turkey

    Nuray Yazıhan, Mehtap Kacar Kocak & Ethem Akcıl

  2. Physiology Department, Baskent University, Ankara, Turkey

    Nuray Yazıhan

Authors
  1. Nuray Yazıhan
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  2. Mehtap Kacar Kocak
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  3. Ethem Akcıl
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Corresponding author

Correspondence to Nuray Yazıhan .

Editor information

Editors and Affiliations

  1. Faculty of Medicine, Faculty of Biochemistry, Yeni Yüzyıl University, Yilanli Ayazma 26, Istanbul, 34000, Istanbul, Turkey

    Mine Ergüven

  2. , Department of Health Science, Aichi Gakuin University, 12 Araike, Iwasakicho, Nisshin, Aichi, Japan

    Takashi Muramatsu

  3. , Department of Histology and Embryology, Istanbul University Faculty of Medicine, Millet, Istanbul, Turkey

    Ayhan Bilir

Additional information

Funding: This chapter contains data from studies supported by TUBITAK-BMBF (SBAG104S329, SBAG108S262).

Conflict of interest: We certify that there is no conflict of interest with any financial organization regarding the material discussed in the manuscript.

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Yazıhan, N., Kocak, M.K., Akcıl, E. (2012). Midkine in Inflammation and Inflammatory Diseases. In: Ergüven, M., Muramatsu, T., Bilir, A. (eds) Midkine: From Embryogenesis to Pathogenesis and Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4234-5_7

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