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Granulocyte-macrophage colony-stimulating factor

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Principles of Cancer Biotherapy

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Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of the colony-stimulating factors whose name is derived from its major target cell lineages. Since the original studies, which characterized its ability to stimulate the clonal proliferation of myel-oid precursors, however, a broader range of biologic effects on mature, effector cells, and the immune system, have been identified. These expanded areas of activity have carried its more recent clinical application beyond that of ‘colony-stimulating factor’ into the realm of immunomodulation.

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Authors and Affiliations

  1. Department of Microbiology, Monash University, Victoria, Australia

    George Morstyn

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  1. Maryann Foote
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  1. Hematology-Oncology Associates of Southeast Missouri Hospital, Southeast Medical Plaza, Cape Girardeau, MO, USA

    Robert K. Oldham

  2. Hoag Cancer Center, Newport Beach, CA, USA

    Robert O. Dillman

  3. University of California, Irvine, CA, USA

    Robert O. Dillman

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Foote, M., Morstyn, G. (2009). Granulocyte-macrophage colony-stimulating factor. In: Oldham, R.K., Dillman, R.O. (eds) Principles of Cancer Biotherapy. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2289-9_18

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