Abstract
Over the years a number of ways to overcome the discrepancy between the need and the availability of lungs for transplantation have been explored, including the use of lung allocation scores and the implementation of standardized donor management protocols. In the last decade several authors have extended lung donor criteria to increase the pool of organs, unfortunately with controversial results. However, the available evidence in favor or against the commonly used lung donor selection criteria leaves a large number of uncertainties in the lung donation process.
Recently, the feasibility and safety of transplanting high-risk donor lungs that have undergone ex vivo lung perfusion (EVLP) have been successfully documented. EVLP allows to evaluate before transplantation donor lungs the function of which is doubtful and to recondition injured donor lungs, thus increasing the number of organs available for transplantation This possibility has brought a new paradigm in the selection of lungs suitable for transplantation.
Ex vivo lung perfusion to recondition donor lungs before transplantation has a number of advantages and, as an emerging innovative technique, has opened a new field of research in the transplantation community.
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Valenza, F., Fumagalli, J., Salice, V., Gattinoni, L. (2014). Lung Reconditioning. In: Sangalli, F., Patroniti, N., Pesenti, A. (eds) ECMO-Extracorporeal Life Support in Adults. Springer, Milano. https://doi.org/10.1007/978-88-470-5427-1_29
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DOI: https://doi.org/10.1007/978-88-470-5427-1_29
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