Abstract
The jaw is a horseshoe shaped structure with a concavity that runs dorsally. It presents an anterior and a posterior side. The jaw ramii are quadrilateral expansions that run obliquely upwards and downwards and are compressed on the lateromedial side. The mandible, which has a membranous origin, develops in the first branchial arch, where there is already a cartilaginous skeleton. A relative increase in mechanical stimulation of the jaw results in the marked neodeposition of osseous tissue that is more intensively and rapidly reabsorbed at sites not subjected to pressure. Mandibular bone is subject to normal turnover that is manifested as bone remodeling. While remodelling also involves the gingival tissue, it is unclear whether osteonecrosis of the jaw, such as occurs in patients treated with bisphosphonates, originates in the bone or in the oral mucosa. However, it has been shown that oral mucosal cells with disrupted talin function are unable to form focal adhesions and exhibit spreading defects, whereas cells with vinculin disruption can form focal adhesions but display a reduced ability to spread and an increase in cell motility.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Priddle H, Hemmings L, Monkeley S et al (1998) Disruption of the talin gene compromises focal adhesion assembly in undifferentiated but not differentiated embryonic stem cells. J Cell Biol 142:1121–1133
Xu WM, Coll JL, Adamson ED (1998) Rescue of the mutant phenotype by reexpression of full-length vinculin in null F9 cells; effects on cell locomotion by domain deleted vinculin. J Cell Sci 111:1535–1544
Nastro Siniscalchi E, Cutroneo G, Catalfamo L et al (2010) Immunohistochemial evaluation of sarcoglycans and integrins in gingival epithelium of multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw. Oncol Rep 24:129–134
Bertoldo F, Santini D, Lo Cascio V (2007) Bisphosphonates and osteomyelitis of the jaw: a pathogenic puzzle. Nat Clin Pract Oncol 4:711–721
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer Milan
About this chapter
Cite this chapter
Cutroneo, G. (2012). Biomorphology in BIONJ: Anatomy and Histology. In: De Ponte, F. (eds) Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach. Springer, Milano. https://doi.org/10.1007/978-88-470-2083-2_6
Download citation
DOI: https://doi.org/10.1007/978-88-470-2083-2_6
Published:
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-2082-5
Online ISBN: 978-88-470-2083-2
eBook Packages: MedicineMedicine (R0)