Skip to main content
SpringerLink
Log in

FGF System and GAGs

  • Living reference work entry
  • First Online:
Glycoscience: Biology and Medicine

  • 71 Accesses

Abstract

In the fibroblast growth factor (FGF) system, sulfated glycosaminoglycans (GAGs) play very important roles. They interact with most FGF ligands and their receptors (FGFRs) and enable formation of active and stable signaling complexes composed of FGF-FGFR or FGF-FGFR/coreceptor. The fine structures of GAGs, particularly position-specific O-sulfation patterns, determine the GAGs’ regulatory activity toward specific FGFs and FGFRs.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Similar content being viewed by others

References

  • Asada M, Shinomiya M, Suzuki M, Honda E, Sugimoto R, Ikekita M, Imamura T (2009) Glycosaminoglycan affinity of the complete fibroblast growth factor family. Biochim Biophys Acta 1790(1):40–48

    Article  CAS  PubMed  Google Scholar 

  • Imamura T, Mitsui Y (1987) Heparan sulfate and heparin as a potentiator or a suppressor of growth of normal and transformed vascular endothelial cells. Exp Cell Res 172(1):92–100

    Article  CAS  PubMed  Google Scholar 

  • Kan M, Wang F, Xu J, Crabb JW, Hou J, McKeehan WL (1993) An essential heparin-binding domain in the fibroblast growth factor receptor kinase. Science 259(5103):1918–1921

    Article  CAS  PubMed  Google Scholar 

  • Maciag T, Mehlman T, Friesel R, Schreiber AB (1984) Heparin binds endothelial cell growth factor, the principal endothelial cell mitogen in bovine brain. Science 225(4665):932–935

    Article  CAS  PubMed  Google Scholar 

  • Nakamura M, Uehara Y, Asada M, Honda E, Nagai N, Kimata K, Suzuki M, Imamura T (2011) Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho. J Biol Chem 286(30):26418–26423

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Ornitz DM, Itoh N (2001) Fibroblast growth factors. Genome Biol. 2(3):REVIEWS3005

    Google Scholar 

  • Sugaya N, Habuchi H, Nagai N, Ashikari-Hada S, Kimata K (2008) 6-O-sulfation of heparan sulfate differentially regulates various fibroblast growth factor-dependent signalings in culture. J Biol Chem 283(16):10366–10376

    Article  CAS  PubMed  Google Scholar 

  • Thompson LD, Pantoliano MW, Springer BA (1994) Energetic characterization of the basic fibroblast growth factor-heparin interaction: identification of the heparin binding domain. Biochemistry 33(13):3831–3840

    Article  CAS  PubMed  Google Scholar 

  • Thornton SC, Mueller SN, Levine EM (1983) Human endothelial cells: use of heparin in cloning and long-term serial cultivation. Science 222(4624):623–625

    Article  CAS  PubMed  Google Scholar 

  • Yoneda A, Asada M, Oda Y, Suzuki M, Imamura T (2000) Engineering of an FGF-proteoglycan fusion protein with heparin-independent, mitogenic activity. Nat Biotechnol 18(6):641–644

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Signaling Molecules Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, 305-8566, Tsukuba, Ibaraki, Japan

    Toru Imamura

  2. Cell Regulation Laboratory, School of Bioscience and Biotechnology, Tokyo University of Technology, 1404-1 Katakuramachi, 192-0982, Hachioji, Tokyo, Japan

    Toru Imamura

Authors
  1. Toru Imamura
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Toru Imamura .

Editor information

Editors and Affiliations

  1. Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

    Tamao Endo

  2. Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

    Peter H. Seeberger

  3. Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Gerald W. Hart

  4. Academia Sinica, Nankang, Taipei, Taiwan

    Chi-Huey Wong

  5. Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Saitama, Japan

    Naoyuki Taniguchi

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Japan

About this entry

Cite this entry

Imamura, T. (2014). FGF System and GAGs. In: Endo, T., Seeberger, P., Hart, G., Wong, CH., Taniguchi, N. (eds) Glycoscience: Biology and Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54836-2_57-1

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-54836-2_57-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Tokyo

  • Online ISBN: 978-4-431-54836-2

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation