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Core Fucosylation of N-linked Glycan for Fine-Tuning TGF-β Receptor Function

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Glycoscience: Biology and Medicine

Abstract

Core fucosylation of glycans regulate diverse biological functions through the modification of targeting proteins, such as TGF-β receptors, EGF receptor, integrin, VEGF receptor, and immunoglobulin mu heavy chain. In the TGF-β signaling transduction, fine-tuning of core fucosylation of on TGF-β receptor amplified the biological effects of this pathway in the lung and kidney and neurite outgrowth. Significant alterations of pathology and physiology were observed in both animal and cell models.

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Authors and Affiliations

  1. Vaccine Production Program Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA

    Xiangchun Wang

  2. Systems Glycobiology Research Group, Global Research Cluster, RIKEN, RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, 2-1 Hirosawa 351-0198, Wako, Saitama, Japan

    Naoyuki Taniguchi

Authors
  1. Xiangchun Wang
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  2. Naoyuki Taniguchi
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Corresponding author

Correspondence to Xiangchun Wang .

Editor information

Editors and Affiliations

  1. Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

    Tamao Endo

  2. Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

    Peter H. Seeberger

  3. Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Gerald W. Hart

  4. Academia Sinica, Nankang, Taipei, Taiwan

    Chi-Huey Wong

  5. Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Saitama, Japan

    Naoyuki Taniguchi

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© 2014 Springer Japan

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Wang, X., Taniguchi, N. (2014). Core Fucosylation of N-linked Glycan for Fine-Tuning TGF-β Receptor Function. In: Endo, T., Seeberger, P., Hart, G., Wong, CH., Taniguchi, N. (eds) Glycoscience: Biology and Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54836-2_56-1

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  • DOI: https://doi.org/10.1007/978-4-431-54836-2_56-1

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  • Publisher Name: Springer, Tokyo

  • Online ISBN: 978-4-431-54836-2

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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