Abstract
The Nordic Cooling Stroke Study (NOCSS) is a multicenter, multinational, randomized, controlled trial investigating the possible neuroprotective efficacy of induced mild hypothermia in acute stroke patients. Cerebral computed tomography scans are performed to exclude hemorrhages, tumors, and other causes simulating the symptoms of an ischemic stroke. The cooling procedure is initiated within 6 h of onset of symptoms and active cooling persists for 9 h, resulting in an average of 12 h of hypothermia. The rewarming is passive. The target temperature is 35°C (deep rectal) and the method of inducing hypothermia is surface cooling using the Arctic Sun (model 200, Medivance, Louisville, CO, USA). The method of inducing hypothermia is deliberately noninvasive and the patients are, moreover, nonanesthetized in order to offer a study design that can be implemented easily and potentially benefit a large percentage of the stroke population.
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© 2004 Springer Japan
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Weber, U.J., Olsen, T.S. (2004). The Nordic Cooling Stroke Study—NOCSS. A Multicenter Study of Induced Mild Hypothermia in Acute Stroke Patients. Ongoing Clinical Trial. In: Hayashi, N., Bullock, M.R., Dietrich, D.W., Maekawa, T., Tamura, A. (eds) Hypothermia for Acute Brain Damage. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53961-2_27
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DOI: https://doi.org/10.1007/978-4-431-53961-2_27
Publisher Name: Springer, Tokyo
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