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Contribution of IL-17 to the pulmonary inflammatory response

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Th 17 Cells: Role in Inflammation and Autoimmune Disease

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Airway exposure to endotoxin and other microbial Toll-like receptor (TLR) agonists induces a rapid production of mediators including IL-1, neutrophil recruitment and bronchoconstriction, which are abrogated in mice deficient for distinct TLRs or the common adaptor molecule myeloid differentiation factor 88 (MyD88). Intranasal IL-17 administration causes acute neutrophilic lung inflammation in a proinflammatory environment. Recent investigations revealed that IL-17 is up-regulated upon endotoxin aerosol exposure and neutralization of IL-17 diminished endotoxininduced inflammation, suggesting a role of endogenous IL-17 in endotoxin-induced lung inflammation. Furthermore, administration of IL-1β mobilizes neutrophils and induces IL-17 production in the lung. Therefore, IL-17 might participates in IL-1β-induced lung inflammation. Importantly, lung injury leads to NALP3 inflammasome activation, leading to IL-1β-dependent acute inflammation. The participation of IL-17 in this response is discussed. In conclusion, TLR-agonist and injury-induced lung inflammation depend in part on IL-1β and IL-17. The role of inflammasome activation cleaving pro-IL-1β leading to mature IL-1ß and IL-1β-dependent IL-17 production and inflammation need to be explored further.

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Author information

Authors and Affiliations

  1. University of Orléans and Molecular Immunology and Embryology, CNRS UMR6218, Orleans, France

    Isabelle Couillin, Pamela Gasse, Silvia Schnyder-Candrian, Bruno Schnyder, François Erard & Bernhard Ryffel

  2. Key-Obs S.A., Orleans, France

    Isabelle Couillin

  3. ULB Bruxelles, Belgium

    Francois Huaux

  4. Biomedical Research Foundation, SBF, Matzingen, Switzerland

    Silvia Schnyder-Candrian, Bruno Schnyder & René Moser

Authors
  1. Isabelle Couillin
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  2. Pamela Gasse
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  3. Francois Huaux
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  4. Silvia Schnyder-Candrian
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  5. Bruno Schnyder
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  6. François Erard
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  7. René Moser
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  8. Bernhard Ryffel
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Editor information

Editors and Affiliations

  1. Molecular Immunology and Embryology, University of Orléans and CNRS UMR6218, 45071, Orléans, France

    Valérie Quesniaux  & Bernhard Ryffel  & 

  2. Novartis Institutes for Biomedical Research, NIBR WSJ 386-906, 4002, Basel, Switzerland

    Franco Di Padova

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© 2009 Birkhäuser Verlag Basel/Switzerland

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Couillin, I. et al. (2009). Contribution of IL-17 to the pulmonary inflammatory response. In: Quesniaux, V., Ryffel, B., Di Padova, F. (eds) Th 17 Cells: Role in Inflammation and Autoimmune Disease. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8681-8_9

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  • DOI: https://doi.org/10.1007/978-3-7643-8681-8_9

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-8680-1

  • Online ISBN: 978-3-7643-8681-8

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