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Is IL-17 required to control tuberculosis?

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Th 17 Cells: Role in Inflammation and Autoimmune Disease

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

We review the state of knowledge regarding the role of IL-17 in tuberculosis (TB). IL-17 is clearly induced following exposure to mycobacteria in mice and humans and therefore its role in both protection and the immunopathological consequences of infection must be fully defined. IL-17-producing T cells can be seen in both mice and humans and these cytokine-producing cells are dependent to a large degree upon IL-23. Based on what we know of the function of IL-17 and the nature of TB, it would be surprising if this were a disease where IL-17 would have a dramatic impact; indeed the experimental data suggests that it is not required for control of bacterial growth. However, while it is clear that IL-17 is present during TB, its function(s) is not yet known. Key questions that will help elucidate function include - the role the mycobacteria plays in induction and regulation of the IL-17 response and the role IL-17 plays in modulating the inflammatory response during chronic disease.

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  1. Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA

    Andrea M. Cooper

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  1. Andrea M. Cooper
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Editors and Affiliations

  1. Molecular Immunology and Embryology, University of Orléans and CNRS UMR6218, 45071, Orléans, France

    Valérie Quesniaux  & Bernhard Ryffel  & 

  2. Novartis Institutes for Biomedical Research, NIBR WSJ 386-906, 4002, Basel, Switzerland

    Franco Di Padova

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Cooper, A.M. (2009). Is IL-17 required to control tuberculosis?. In: Quesniaux, V., Ryffel, B., Di Padova, F. (eds) Th 17 Cells: Role in Inflammation and Autoimmune Disease. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8681-8_12

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  • DOI: https://doi.org/10.1007/978-3-7643-8681-8_12

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-8680-1

  • Online ISBN: 978-3-7643-8681-8

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