Summary
The continuous dopaminergic stimulation provided by infusion of dopamine agonist drugs, is a very effective strategy to control ON-OFF fluctuation in Parkinson’s disease. Lisuride is a potent dopamine agonist drug, very soluble in water and can be administred subcutaneously. Many authors have shown that the subcutaneous infusion of lisuride can control fluctuations when applied in combination with oral levodopa as a 24 hour continuous infusion regimen. In this study, lisuride was given without any other antiparkinsonian medicament and using a 12 hour infusion regimen wherever possible. 13 fluctuating Parkinsonian patients were studied. 6 out of these 13 were satisfactorly treated with lisuride alone and the remaining 7 with a combination of Lisuride + oral levodopa. Only in 3 out of 13 patients the 24 hour infusion regimen was required.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Bittkau S, Przuntek H (1986) Lisuride infusion pump for Parkinson’s disease. Lancet 2: 349
Critchley P, Perez FG, Quinn N, Coleman R, Parkes D, Marsden CD (1986) Psychosis and the lisuride pump. Lancet 2: 349
Marion MH, Stocchi F, Quinn NP, Jenner P, Marsden CD (1986) Repeated levodopa infusions in fluctuating Parkinson’s disease: clinical and pharmacokinetic data. Clin Neuropharmacol 9: 165–181
Nutt JG, Woodward WR, Hammerstad JP, Carter JH, Anderson JL (1984) The on-off phenomenon in Parkinson’s disease: relation to levodopa absorption and transport. N Engl J Med 23: 483–488
Obeso JA, Luquin MR, Martinez-Lage JM (1983) Lisuride infusion for Parkinson’s disease. Ann Neurol 14: 134–139
Obeso JA, Luquin MR, Martinez-Lage JM (1986) Lisuride infusion pump: a device for the treatment of motor fluctuations in Parkinson’s disease. Lancet 1: 467–470
Quinn N, Marion MH, Stocchi F, Jenner P, Marsden CD (1986) Intravenous dopamine agonist studies in Parkinson’s disease. In: Fahn S, Marsden CD, Jenner P, Teychenne P (eds) Recent developments in Parkinson’s disease. Raven Press, New York, pp 247–253
Ruggieri S, Stocchi F, Agnoli A (1986) Lisuride infusion pump for Parkinson’s disease. Lancet 2: 348–349
Shoulson I, Glaubiger GA, Chase TN (1975) On-off response: clinical and biochemical correlations during oral and intravenous levodopa administration in parkinsonian patients. Neurology 25: 1144–1148
Stocchi F, Ruggieri S, Brughitta G, Agnoli A (1986) Problems in daily performances in Parkinson’s disease: the continuous dopaminergic stimulation. J Neural Transm [Suppl] 22: 223–229
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag
About this paper
Cite this paper
Stocchi, F. et al. (1988). Subcutaneous lisuride infusion in Parkinson’s disease: clinical results using different modes of administration. In: Obeso, J.A., Horowski, R., Marsden, C.D. (eds) Continuous Dopaminergic Stimulation in Parkinson’s Disease. Journal of Neural Transmission, vol 27. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8954-2_4
Download citation
DOI: https://doi.org/10.1007/978-3-7091-8954-2_4
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82034-6
Online ISBN: 978-3-7091-8954-2
eBook Packages: Springer Book Archive