Abstract
The ability of nuclear receptors to function as ligand-dependent transcription factors depends on the recruitment of cofactors in the vicinity of target genes where they play a number of distinct roles. The activation of genes depends on overcoming the barrier to transcription formed by the packaging of DNA into dense chromatin to allow the subsequent recruitment of transcription machinery. This process can be reversed either to repress gene transcription transiently or ultimately to silence genes completely when they are packaged into heterochromatin. These alterations are achieved by the recruitment of coactivators and corepressors that reorganize chromatin templates and recruit basal transcription factors and RNA polymerase II.
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Parker, M., White, R., Leonardsson, G., Milligan, S., Steel, J. (2004). Identification of RIP140 as a Nuclear Receptor Cofactor with a Role in Female Reproduction. In: Korach, K.S., Hillisch, A., Fritzemeier, K.H. (eds) New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy. Ernst Schering Research Foundation Workshop, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05386-7_2
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DOI: https://doi.org/10.1007/978-3-662-05386-7_2
Publisher Name: Springer, Berlin, Heidelberg
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