Skip to main content
SpringerLink
Log in
Book cover

Genetics of the Epilepsies pp 145–155Cite as

Twin Studies in Epilepsy

  • Conference paper

Abstract

A number of twin studies of epilepsy, both larger series and individual case studies, have been reported. These have shown clearly that both genetic and environmental factors are involved, but they have not contributed significantly to the understanding of basic mechanisms. Meanwhile, there has been rapid progress in the neurosciences, with respect to brain structure and function, brain imaging, neurophysiology, and biochemistry at the cellular and molecular levels [8, 27]. New questions have arisen and new methods for study have been developed.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Allen G (1955) Comments on the analysis of twin samples. Acta Genet Med Gemello1 4: 143–160

    CAS  Google Scholar 

  2. Allen G (1965) Twin research: problems and prospects. Prog Med Genet 4: 242–269

    PubMed  CAS  Google Scholar 

  3. Barslund I, Danielsen J (1963) Temporal epilepsy in monozygotic twins. Epilepsia 4: 138–150

    Article  PubMed  CAS  Google Scholar 

  4. Bertelsen A, Gottesman II (1986) Offspring of twin pairs discordant for psychiatric illness. Paper presented at the Vth international congress twin studies, Sept 15–19, Amsterdam

    Google Scholar 

  5. Cameron AH, Edwards JH, Derom R, Thiery M, Boelaert R (1983) The value of twin surveys in the study of malformations. Eur J Obstet Gynecol Reprod Biol 14: 347–356

    Article  PubMed  CAS  Google Scholar 

  6. Campostrini R, Zaccara G, Rossi L, Paganini M, Dorigotti A, Zappoli R (1985) Valproateinduced hyperammonaemia in two epileptic identical twins. J Neurol 232: 167–168

    Article  PubMed  CAS  Google Scholar 

  7. Daly D, Bickford RG (1951) Electroencephalographic studies of identical twins with photo-epilepsy. EEG Clin Neurophysiol 3: 245–249

    Article  CAS  Google Scholar 

  8. Delgado-Escueta AV, Ward AA Jr, Woodbury DM, Porter RJ (eds) (1986) Advances in neurology, vol 44. Raven, New York

    Google Scholar 

  9. Eaves Li (1982) The utility of twins. In: Anderson VE, Hauser WA, Penry JK, Sing CF (eds) Genetic basis of the epilepsies. Raven, New York

    Google Scholar 

  10. Forster F, Daly R (1973) Reading epilepsy in identical twins. Trans Am Neurol Assoc 98: 186–188

    PubMed  CAS  Google Scholar 

  11. Frantzen E, Lennox-Buchthal M, Nygaard A, Stene J (1970) A genetic study of febrile convulsions. Neurology 20: 909–917

    PubMed  CAS  Google Scholar 

  12. Haines JL, Panter SS, Rich SS, Eaton JW, Tsai MY, Anderson VE (1986) Reduced plasma haptoglobin and urinary taurine in familial seizures identified through the multisib strategy. Am J Med Genet 24: 723–734

    Article  PubMed  CAS  Google Scholar 

  13. Harvald B, Hauge M (1965) Hereditary factors elucidated by twin studies. In: Neel JV, Shaw MW, Schull WJ (eds) Genetics and the epidemiology of chronic diseases. Public Health Service Publication No 1163, Washington DC

    Google Scholar 

  14. Hrubec Z, Robinette CD (1984) The study of human twins in medical research. N Engl J Med 310: 435–441

    Article  PubMed  CAS  Google Scholar 

  15. Hurst R, Lenn NJ (1986) Partial seizures in monozygous twins. Epilepsia 27: 121–123

    Article  PubMed  CAS  Google Scholar 

  16. Inouye E (1960) Observations on forty twin index cases with chronic epilepsy and their co-twins. J Nery Ment Dis 130: 401–416

    Article  CAS  Google Scholar 

  17. Lennox WG, Lennox MA (1960) Epilepsy and related disorders. Little, Brown, Boston

    Google Scholar 

  18. Lennox-Buchthal M (1971) Febrile and nocturnal convulsions in monozygotic twins. Epilepsia 12: 147–156

    Article  PubMed  CAS  Google Scholar 

  19. Lennox-Buchthal MA (1973) Febrile convulsions. A reappraisal. EEG Clin Neurophysiol (suppl 32 ): 1–132

    Google Scholar 

  20. McGue M, Rao DC, Isélius L, Russell JM (1985) Resolution of genetic and cultural inheritance in twin families by path analysis: Application to HDL cholesterol. Am J Hum Genet 37: 998–1014

    Google Scholar 

  21. Moll PP, Sing CF (1979) Sampling strategies for the analysis of quantitative traits. In: Sing CF, Skolnick M (eds) Genetic analysis of common diseases: applications to predictive factors on coronary disease. Liss, New York

    Google Scholar 

  22. Nance WE, Corey LA, Boughman JA (1978) Monozygotic twin kinships: a new design for genetic and epidemiological research. In: Morton NE, Chung CS (eds) Genetic epidemiology. Academic, New York

    Google Scholar 

  23. Newmark ME, Penry JK (eds) (1980) Genetics of epilepsy: a review. Raven, New York

    Google Scholar 

  24. Panter SS, Sadrzadeh SM, Hallaway PE, Haines J, Anderson VE, Eaton JW (1985) Hypohaptoglobinemia: a possible predisposition to epilepsy. Trans Assoc Am Physicians 97: 5662

    Google Scholar 

  25. Phelan MC, Pellock JM, Nance WE (1982) Discordant expression of fetal hydantoin syndrome in heteropaternal dizygotic twins. N Engl J Med 307: 99–101

    Article  PubMed  CAS  Google Scholar 

  26. Propping P, Vogel F (1976) Twin studies in medical genetics. Acta Genet Med Gemellol 25: 249–258

    PubMed  CAS  Google Scholar 

  27. Rosenberg MB, Hansen C Jr, Breakefield XO (1985) Molecular genetic approaches to neurologic and psychiatric diseases. Progr Neurobiol 24: 95–140

    Article  CAS  Google Scholar 

  28. Schiettz-Christensen E (1972) Genetic factors in febrile convulsions: an investigation of 64 same-sexed twin pairs. Acta Neurol Scand 48: 538–546

    Article  Google Scholar 

  29. Schiettz-Christensen E (1973 a) Neurological findings in twins discordant for febrile convulsions. Acta Neurol Scand 49:368–378

    Article  Google Scholar 

  30. Schiettz-Christensen E (1973 b) Role of birth history in the aetiology and course of febrile convulsions. A twin study. Neuropaediatrie 4: 239–244

    Google Scholar 

  31. Schiettz-Christensen E, Bruhn P (1973) Intelligence, behaviour and scholastic achievement subsequent to febrile convulsions: an analysis of discordant twin pairs. Develop Med Child Neurol 15: 565–575

    Article  Google Scholar 

  32. Schiottz-Christensen E, Hammerberg PE (1975) EEG in twins with febrile convulsions. Follow-up on 59 pairs of the same sex. Neuropaediatrie 6: 142–150

    Article  Google Scholar 

  33. Smith C (1970) Heritability of liability and concordance in monozygotic twins. Ann Hum Genet 34: 85–91

    Article  PubMed  CAS  Google Scholar 

  34. Smith C (1974) Concordance in twins: methods and interpretations. Am J Hum Genet 26: 454–466

    PubMed  CAS  Google Scholar 

  35. Tsuboi T, Okada S (1985) The genetics of epilepsy. In: Sakai T, Tsuboi T (eds) Genetic aspects of human behavior. Igaku-Shoin, Tokyo

    Google Scholar 

  36. Vogel F (1988) Genetic variation of the normal human EEG (this volume)

    Google Scholar 

  37. Those interested may write to: Epilepsy Twin Registry, Dight Laboratories, University of Minnesota, 400 Church Street S E, Minneapolis, MN 55455, USA

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Genetics and Cell Biology, Dight Laboratories, University of Minnesota, 400 Church Street S. E., Minneapolis, MN, 55455, USA

    V. E. Anderson & K. J. Wilcox

  2. Department of Laboratory Medicine and Pathology, Box 511 Mayo, University of Minnesota, Hospital and Clinic, 500 Harvard Street S. E., Minneapolis, MN, 55455, USA

    S. S. Rich

  3. Department of Neurology, Box 389 Mayo, University of Minnesota, Hospital and Clinic, 500 Harvard Street S. E., Minneapolis, MN, 55455, USA

    I. E. Leppik

  4. G. H. Sergievsky Center, Columbia University, 630 West 168th Street, New York, NY, 10032, USA

    W. A. Hauser

Authors
  1. V. E. Anderson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. J. Wilcox
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. S. Rich
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I. E. Leppik
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. W. A. Hauser
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Neurologische Abteilung, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Spandauer Damm 130, D-1000, Berlin 19, Germany

    Gertrud Beck-Mannagetta M.D. (Assistant Professor of Neurology) & Dieter Janz M.D. (Professor of Neurology) (Assistant Professor of Neurology) &  (Professor of Neurology)

  2. Dight Laboratories, University of Minnesota, 400 Church Street S.E., 55455, Minneapolis, MN, USA

    V. Elving Anderson M.D. (Professor of Genetics and Cell Biology) (Professor of Genetics and Cell Biology)

  3. Abteilung für Neuropädiatrie, Universität Kiel, Schwanenweg 20, D-2300, Kiel, Germany

    Hermann Doose M.D. (Professor of Pediatrics) (Professor of Pediatrics)

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Anderson, V.E., Wilcox, K.J., Rich, S.S., Leppik, I.E., Hauser, W.A. (1989). Twin Studies in Epilepsy. In: Beck-Mannagetta, G., Anderson, V.E., Doose, H., Janz, D. (eds) Genetics of the Epilepsies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95553-2_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-95553-2_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-95555-6

  • Online ISBN: 978-3-642-95553-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation