Abstract
Prostacyclin is the major prostanoid formed in the vascular wall of conduit arteries. The most important source are endothelial cells which represent only about 5% of the total mass of the vascular wall, but produce about 40% of its prostacyclin (Moncada et al. 1977). Prostacyclin is a potent vasodilator (and an inhibitor of platelet aggregation). Under normal conditions vascular production of prostaglandins is low, however, it can be stimulated by a variety of hormones, autacoids and drugs (Schrör 1985) (cf. below). One major function of the prostacyclin produced could be the mediation or attenuation of the effect of other vasodilator or vasoconstrictor agents, respectively.
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References
Busse R, Trogisch G, Bassenge E (1985) The role of endothelium in control of vascular tone. Basic Res. Cardiol. 80: 475–490
Cherry PD, Furchgott RF, Zawadzki JV, Jothianandan D (1982) The role of endothelial cells in the relaxation of isolated arteries by bradykinin. Proc. Natl. Acad. Sci. USA 79: 2106–2110
Cocks TM, Angus JA, Campbell JH, Campbell GR (1985) Release and properties of endothelium-derived relaxing factor (EDRF) from endothelial cells in culture. J. Cell Physiol. 123: 310–320
Dudel C, Förstermann U Endothelium-dependent vasdilation of resistance arteries in rabbit hindlimb in vivo (in preparation)
Förstermann U, Neufang B (1984) The endothelium-dependent vasodilator effect of acetylcholine: a characterization of the endothelial relaxing factor with inhibitors of arachidonic acid metabolism. Eur. J. Pharmacol. 103: 65–70
Förstermann U, Trogisch G, Busse R (1984a) Species dependent differences in the nature of endothelium-derived vascular relaxing factor. Eur. J. Pharmacol. 106: 639–643
Förstermann U, Hertting G, Neufang B (1984b) The importance of endogenous prostaglandins other than prostacyclin for the modulation of contractility of some rabbit blood vessels. Br. J. Pharmacol. 81: 623–630
Förstermann U, Neufang B (1985) Endothelium-dependent vasodilation by melittin: are lipoxygenase products involved ? Am. J. Physiol. 249: H14 - H19
Förstermann U, Hertting G, Neufang B (1986a) The role of endothelial and non-endothelial prostaglandins in the relaxation of isolated blood vessels of the rabbit induced by acetylcholine and bradykinin. Br. J. Pharmacol. 87: 521–532
Förstermann U, Goppelt-Strübe M, Frölich JC, Busse R (1986b) Inhibitors of acyl-coenzyme A: lysolecithin acyltransferase activate the production of endothelium-derived vascular relaxing factor. J. Pharmacol. Exp. Ther. 238: 352–359
Förstermann U, Mülsch A, Böhme E, Busse R (1986c) Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries. Circ. Res. 58: 531–538
Förstermann U, Frölich JC Endothelium-dependent relaxations by acetylcholine, A23187 and melittin are suppressed by lipoxygenase inhibitors and by inhibitors of cytochrome P-450 monooxygenase. (submitted a)
Förstermann U, Burgwitz K, Frölich JC The effect of non-steroidal phospholipase inhibitors and glucocorticoids on endothelium-dependent relaxation of rabbit aorta induced by different agents (submitted b)
Furchgott RF, Zawadzki JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature (Lond.) 288: 373–376
Furchgott RF (1984) The role of endothelium in the responses of vascular smooth muscle to drugs. Annu. Rev. Pharmacol. Toxicol. 24: 175–197
Griffith TM, Edwards DH, Lewis MJ, Newby AC, Henderson AH (1984) The nature of endothelium-derived vascular relaxant factor. Nature (Lond.) 308: 645–647
Lands WEM, Merkl I (1963) Metabolism of glycerolipids. III. Reactivity of various acyl esters of coenzyme A with a’-acylglycerophorylcholine, and positional specificities in lecithin synthesis. J. Biol. Chem. 238: 898–904
Moncada S, Herman AG, Higgs EA, Vane JR (1977) Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. Thromb. Res. 11: 323–344
Murad F (1986) Cylic guanosine monophosphate as a mediator of vasodilation. J. Clin. Invest. 78: 1–5
Schrör K (1985) Prostaglandin, other eicosanoids and endothelial cells. Basic Res. Cardiol. 80: 502–514
Schrör K (1986) In: Iloprost - 1st International Symposium, R.J. Gryglewski, G. Stock (Eds.) Springer, Berlin (in press)
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Förstermann, U. (1987). Regulation of vascular tone by prostaglandins and endothelium-derived relaxing factor. In: Schettler, G. (eds) Molecular Biology of the Arterial Wall. Veröffentlichungen aus der Geomedizinischen Forschungsstelle der Heidelberger Akademie der Wissenschaften, vol 1987/88 / 1987/4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83118-8_36
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DOI: https://doi.org/10.1007/978-3-642-83118-8_36
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