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Ion Transport in Mutant Cell Lines: Possibilities for Analysis

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Epithelial Secretion of Water and Electrolytes

Abstract

Two reasons can be identified which make a study of ion transport in mutant cell lines of importance. First, mutants provide the first stage for molecular genetic studies from which the molecular identification of the transporting proteins can eventually be derived. Incidentally, if the phenotypic characteristics of the mutant are sufficiently different from the wild type, then important aspects of cell function overall may be revealed. The second reason, which is not unconnected with the first, is that a number of identifiable disease states appear to be associated with a mutation affecting cellular transport mechanisms. The obvious examples are cystic fibrosis and chloridorrhoea.

Work from the authors laboratory referred to in this review was supported by NIH HL17705.

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Authors
  1. A. W. Cuthbert
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Editors and Affiliations

  1. Department of Physiology, University of Sydney, Sydney, NSW, 2006, Australia

    J. A. Young DSc MD (Qld) FAA FRACP

  2. Department of Physiology, Faculty of Medicine, University of Hong Kong, Li Shu Fan Building, Sassoon Road, Hong Kong

    P. Y. D. Wong MA PhD (Cantab) DSc (Lond) FRSC FIBiol

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© 1990 Springer-Verlag Berlin · Heidelberg

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Cuthbert, A.W. (1990). Ion Transport in Mutant Cell Lines: Possibilities for Analysis. In: Young, J.A., Wong, P.Y.D. (eds) Epithelial Secretion of Water and Electrolytes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75033-5_7

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  • DOI: https://doi.org/10.1007/978-3-642-75033-5_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75035-9

  • Online ISBN: 978-3-642-75033-5

  • eBook Packages: Springer Book Archive

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