Abstract
Three anatomically distinct pairs of major salivary glands (parotid, mandibular, and sublingual) and several different minor salivary glands are responsible for the production of saliva. This review article will focus primarily on the rat mandibular and parotid glands since most of our current understanding of the actual cellular processes involved in exocytosis has come from studies on these two tissues.
This work was supported by NIH Grants DE-07689 and DE-07201.
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References
Arkle S, Pickford PD, Schofield PS, Ward C, Argent BE (1986) Mechanism of the inhibitory effect of trifluoperazine on isoprenaline-evoked amylase secretion from isolated rat parotid glands. Biochem Pharmacol 35: 4121–4124
Baldys-Waglegorska A, Pour A, Moriarty CM, Dowd F (1987) The effect of calcium and cyclic AMP on amylase release in digitonin-permeabilized parotid gland cells. Biochim Biophys Acta 929: 190–196
Baum BJ, Colpo FT, Filburn CR (1981a) Characterization and relationship to exocrine secretion of rat parotid gland cyclic AMP-dependent protein kinase. Arch Oral Biol 26: 333–357
Baum BJ, Frieberg JM, Ito H, Roth GS, Filburn CR (1981b) Beta-adrenergic regulation of protein phosphorylation and its relationship to exocrine secretion in dispersed rat parotid gland acinar cell. J Biol Chem 256: 9731–9736
Bonis D, Giraird F, Rossignol B (1986) Inositol trisphosphate-induced Ca2+ release from rat parotid subcellular fractions. Biol Cell 57: 271–274
Butcher FR (1980) Regulation of calcium efflux from isolated rat parotid cells. Biochim Biophys Acta 630: 254–260
Butcher FR, Putney JW (1980) Regulation of parotid gland function by cyclic nucleotides and calcium. Adv Cyclic Nucleotide Res 13: 215–249
Domenech EM, Söling H-D (1987) Effects of stimulation of muscarinic and of beta-catecholamine receptors on the intracellular distribution of protein kinase C in guinea pig exocrine glands. Biochem J 242: 749–754
Douglas WW, Poisner AM (1963) The influence of calcium on the secretory response of the submaxillary gland to acetylcholine or to noradrenaline. J Physiol (Lond) 165: 528–541
Dowd F, Cheung P, Warren J, Faerber T, Traub D (1985) Comparison of cyclic AMP-dependent protein kinases from salivary glands of four species. J Dent Res 64: 1199–1203
Dowd F, Watson EL, Lau Y-S, Justin J, Pasienuik J, Jacobson KL (1987) Calcium-dependent protein kinase reactions associated with parotid gland secretory granule membranes. J Dent Res 66: 557–563
Dreux C, Imhoff V, Huleux C, Busson S, Rossignol B (1986) Forskolin, a tool for rat parotid secretion studies: 45Ca efflux is not related to cAMP. Am J Physiol 251: C754–C762
Fleming N, Bilan PT, Sliwinski-Lis E (1986) Effects of a phorbol ester and diacylglycerols on secretion of mucin and arginine esterase by rat submandibular gland cells. Pflügers Arch 406: 6–11
Freedman SD, Jamieson JD (1982a) Hormone-induced protein phosphorylation. I. Relationship between secretagogue action and endogenous protein phosphorylation in intact cells from the exocrine pancreas and parotid. J Cell Biol 95: 903–908
Freedman SD, Jamieson JD (1982b) Hormone-induced protein phosphorylation. II. Localization to the ribosomal fraction from rat exocrine pancreas and parotid of a 29,000-dalton protein phosphorylated in situ in response to secretagogues. J Cell Biol 95:909–917
Hand AR (1987) Functional ultrastructure of the salivary glands. In: Sreebny LM (ed) The salivary system. CRC, Boca Raton, pp 43–67
Henne V, Piiper A, Söling H-D (1987) Inositol 1,4,5-trisphosphate and 5’-GTP induce calcium release from different intracellular pools. FEBS Lett 218: 153–158
Hughes AR, Takemura H, Putney JW (1988) Kinetics of inositol 1,4,5-trisphosphate and inositol cyclic l:2,4,5-trisphosphate metabolism in intact rat parotid acinar cells. J Biol Chem 263: 10314–10319
Hurley TW, Martinez JR (1985) Characterization of the kinetic and regulatory properties of high-affinity Ca2+ -ATPase activity in acinar preparation of rat submandibular salivary glands. Arch Oral Biol 30: 587–594
Hurley TW, Martinez JR (1986) Characterization and localization of two forms of active Ca2+ transport in vesicles derived from rat submandibular glands. Cell Calcium 7: 49–59
Immelmann A, Söling H-D (1983) ATP-dependent calcium sequestration and calcium/ATP stoichiometry in isolated microsomes from guinea pig parotid glands. FEBS Lett 162: 406–410
Jahn R, Söling H-D (1981) Phosphorylation of the same specific protein during amylase release evoked by beta-adrenergic or cholinergic agonists in rat and mouse parotid glands. Proc Natl Acad Sci USA 78: 6903–6906
Jahn R, Söling H-D (1983) Phosphorylation of the ribosomal protein S6 in response to secretagogues in the guinea pig exocrine pancreas, parotid and lacrimal gland. FEBS Lett 153: 71–76
Jahn R, Unger C, Söling H-D (1980) Specific protein phosphorylation during stimulation of amylase secretion by beta-agonists or dibutyryl adenosine 3′,5′-monophosphate in the rat parotid gland. Eur J Biochem 112: 345–352
Kanagasuntheram P, Rändle PJ (1976) Calcium metabolism and amylase release in rat parotid acinar cells. Biochem J 160: 547–564
Kanagasuntheram P, Teo TS (1982a) Parotid microsomal Ca2+ transport. Subcellular localization and characterization. Biochem J 298: 789–794
Kanagasuntheram P, Teo TS (1982b) Calmodulin-sensitive ATP-dependent calcium transport by the rat parotid endoplasmic reticulum. FEBS Lett 141: 233–236
McPherson MA, Dormer RL (1984) Mucin release and calcium fluxes in isolated rat submandibular acini. Biochem J 224: 473–481
Merrit JE, Rink TJ (1987) Regulation of cytosolic free calcium in fura-2 loaded rat parotid acinar cells. J Biol Chem 262: 17362–17369
Mieskes G, Söling H-D (1987) Protein phosphatases of the guinea-pig parotid gland. Eur J Biochem 167: 377–382
Nyjar MA, Pritchard ET (1971) Calcium binding by a plasma membrane fraction isolated from rat submandibular gland. Biochim Biophys Acta 323: 391–395
Padel U, Söling H-D (1985) Phosphorylation of the ribosomal protein S6 during agonist-induced exocytosis in exocrine glands is catalyzed by calcium-phospholipid-dependent protein kinase (protein kinase C). Eur J Biochem 151: 1–10
Perec CJ, Alonso GJ (1971) The effect of denervation on ATP dependent calcium uptake by microsomes of the submaxillary gland of rats. Experientia 27: 897–898
Piascik MT, Babich M, Jacobson KL, Watson EL (1986) Calmodulin activation and calcium regulation of parotid gland adlenylate cyclase. Am J Physiol 250: C642–C645
Plewe G, Jahn R, Immelmann A, Bode C, Söling H-D (1984) Specific phosphorylation of a protein in calcium accumulating endoplasmic reticulum from rat parotid glands following stimulation by agonists involving cAMP as second messenger. FEBS Lett 166: 96–103
Putney JW, Weiss SJ, Leslie BA, Marier SH (1977) Is calcium the final mediator of exocytosis in the rat parotid gland? J pharmacol Exp Ther 203: 144–155
Putney JW, McKinney JS, Aub DL, Leslie BA (1984) Phorbol ester-induced protein secretion in parotid gland. Relationship to the role of inositol lipid breakdown and protein kinase C activation in stimulus-secretion coupling. Mol Pharmacol 26: 261–266
Quissell DO, Barzen KA (1980) Secretory response of dispersed rat submandibular cells. II. Mucin secretion. Am J Physiol 238: C99–C106
Quissell DO, Barzen KA, Lafferty JL (1981) Role of calcium and cAMP in the regulation of rat submandibular mucin secretion. Am J Physiol 241: C76–C85
Quissell DO, Barzen KA, Deisher LM (1983a) Role of cyclic AMP-dependent protein kinase activation in regulating rat submandibular mucin secretion. Biochim Biophys Acta 762: 215–220
Quissell DO, Deisher LM, Barzen KA (1983b) Role of protein phosphorylation in regulating rat submandibular mucin secretion. Am J Physiol 245: G44–G53
Quissell DO, Deisher LM, Barzen KA (1985) The rate-determining step in cAMP-mediated exocytosis in the rat parotid and submandibular glands appear to involve analogous 26-kDa integral membrane phosphoproteins. Proc Natl Acad Sci USA 82: 3237–3241
Quissell DO, Deisher LM, Barzen KA (1987) Role of protein phosphorylation in rat salivary gland exocytosis. J Dent Res 66: 596–598
Quissell DO, Deisher LM, Barzen KA (1988) Subcellular distribution and activation of rat submandibular cAMP-dependent protein kinase following beta-adrenergic receptor stimulation. Biochim Biophys Acta 969: 28–32
Quissel DO, Barzen KA, Deisher LM (1989) Evidence against a direct role for protein kinase C in rat submandibular mucin secretion. Arch Oral Biol 34: 695–699
Selinger F, Nairn E, Lassar M (1970) ATP-dependent calcium uptake by microsomal preparations from rat parotid and submaxillary glands. Biochim Biophys Acta 203: 326–334
Schneyer LH, Young JA, Schneyer CA (1972) Salivary secretions of electrolytes. Physiol Rev 52: 720–777
Singh J, Brady RC, Dedman JR, Quissell DO (1986) Subcellular distribution of calmodulin and its binding proteins within the rat submandibular gland. Am J Physiol 251: C403–C410
Spearman TN, Butcher FR (1982) Rat parotid gland protein kinase activation. Relationship to enzyme secretion. Mol Pharmacol 21: 121–127
Spearman TN, Butcher FR (1983) The effect of calmodulin antagonists on amylase release from the rat parotid gland in vitro. Pflügers Arch 397: 220–224
Spearman NT, Hurley KP, Olivas R, Ulrich RG, Butcher FR (1984) Subcellular location of stimulus-affected endogenous phosphoproteins in the rat parotid gland. J Cell Biol 99: 1354–1363
Takemura H (1985) Changes in cytosolic free calcium concentration in isolated rat parotid cells by cholinergic and beta-adrenergic agonists. Biochem Biophys Res Commun 131: 1048–1055
Takuma T, Ichida T (1986a) Does cyclic AMP mobilize Ca2+ for amylase secretion from rat parotid cells? Biochim Biophys Acta 887: 113–117
Takuma T, Ichida T (1986b) Phorbol ester stimulates amylase secretion from rat parotid cells. FEBS Lett 199: 53–56
Takuma T, Ichida T (1988) Amylase secretion from saponin-permeabilized parotid cells evoked by cyclic AMP. J Biochem 103: 95–98
Terman BI, Gunter TE (1983) Characterization of the submandibular gland microsomal calcium transport system. Biochim Biophys Acta 730: 151–160
Thiel G, Schmidt WE, Meyer HE, Söling H-D (1988) Purification and characterization of a 22-kDa microsomal protein from rat parotid gland which is phosphorylated following stimulation by agonists involving cAMP as second messenger. Eur J Biochem 170: 643–651
Tojyo Y, Uchida M, Matsumoto Y (1987) Inhibitory effects of calmodulin antagonists on isoproterenol- and dibutyryl cyclic AMP-stimulated amylase release from rat parotid acinar cells. Jpn J Pharmacol 45: 487–491
Watson EL, Siegel IA (1978) Factors affecting calcium accumulation and release in canine submandibular salivary microsomes. Arch Oral Biol 23: 323–328
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Quissell, D.O. (1990). Physiology of Salivary Gland Exocytosis. In: Young, J.A., Wong, P.Y.D. (eds) Epithelial Secretion of Water and Electrolytes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75033-5_14
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DOI: https://doi.org/10.1007/978-3-642-75033-5_14
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