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Production of Three Monoclonal Antibodies — A01, B05, and Cll — Against B-Cell Leukemia

  • Conference paper
Modern Trends in Human Leukemia VII

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 31))

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Abstract

The advent of MoAb technology has greatly facilitated the identification of various subsets of lymphoid cells [1, 2]. However, most studies have been concentrated on acute lymphoblastic and myelocytic leukemias [1-4], and relatively few MoAbs that are directed against surface determinants of chronic lymphocytic cells have been reported [5-7]. The reason may be that CLL cell lines are few in number and are not as well characterized as acute lymphocytic or acute myelocytic leukemia cells. In this report we describe the establishment of three hybridomas which secrete MoAbs against an antigen present on malignant B-lympho-cytes in the peripheral blood of most CLL and some non-T, non-B ALL patients. These newly established MoAbs have unique patterns of reactivity to normal and leukemic cells distinct from other reported MoAbs and may be useful for the characterization of certain malignant B cells, either for clinical purposes or for the staging of leukemic cells.

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Authors and Affiliations

  1. Departments of Medicine, Veterans General Hospital and National Yang-Ming Medical College, Taipei, Taiwan, Republic of China

    P. Chen, C. Chiu, T. Chiou, C. Tzeng, S. Lin, R. Hsieh, H. Yeh & B. N. Chiang

  2. Medical Research, Veterans General Hospital and National Yang-Ming Medical College, Taipei, Taiwan, Republic of China

    C. Ho

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  1. P. Chen
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  2. C. Chiu
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  3. T. Chiou
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  4. C. Tzeng
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  5. C. Ho
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  6. S. Lin
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  7. R. Hsieh
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  8. H. Yeh
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  9. B. N. Chiang
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Editor information

Editors and Affiliations

  1. Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, 2000, Hamburg 20, Germany

    Rolf Neth

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD, 20205, USA

    Robert C. Gallo

  3. Institute of Cancer Research, Chester Beatty Laboratories, Leukemia Research Fund Centre, Fulham Road, London, SW3 6JB, UK

    Melvyn F. Greaves

  4. Abteilung für Hämatologie und Onkologie, Universitäts-Kinderklinik, Martinistraße 52, 2000, Hamburg 20, Germany

    Hartmut Kabisch

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© 1987 Springer-Verlag Berlin Heidelberg

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Chen, P. et al. (1987). Production of Three Monoclonal Antibodies — A01, B05, and Cll — Against B-Cell Leukemia. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_27

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  • DOI: https://doi.org/10.1007/978-3-642-72624-8_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17754-8

  • Online ISBN: 978-3-642-72624-8

  • eBook Packages: Springer Book Archive

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