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Flavoproteins of Known Three-Dimensional Structure

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Biological Oxidations

Abstract

About 50 years ago FMN (Theorell 1935) and FAD (Warburg and Christian 1938) were discovered as prosthetic groups of the old yellow enzyme and of D-amino acid oxidase, respectively. More than 100 flavoenzymes have been described in the meantime (Dixon and Webb 1979); for four of them, structural data are known. These are glycolate oxidase (Lind quist and Bränden 1980), an FMN-dependent enzyme which probably has a chain fold in common with triose phosphate isomerase and one domain of pyruvate kinase, and three FAD-dependent enzymes: ferredoxin-NADP+ reductase (Sheriff and Herriott 1981; Karplus and Herriott 1982) p-hydroxybenzoate hydroxylase (Wierenga et al. 1979; Wierenga et al. 1982; Weijer et al. 1982) and glutathione reductase (Schulz et al. 1978; Thieme et al. 1981; Pai and Schulz 1983). The last mentioned two enzymes have been analyzed in atomic detail. In our presentation, we shall first describe glutathione reductase as a we11-understood flavoenzyme and then compare its structure with p-hydroxybenzoate hydroxylase. Whenever possible we shall include structural aspects of other flavoproteins in our discussion.

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Authors and Affiliations

  1. Institut für Biochemie II der Universität Heidelberg, Im Neuenheimer Feld 328, D-6900, Heidelberg, Germany

    R. H. Schirmer

  2. Max-Planck-Institut für Medizinische Forschung, Jahnstraße 29, D-6900, Heidelberg, Germany

    G. E. Schulz

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  1. R. H. Schirmer
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  2. G. E. Schulz
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  1. Fakultät für Biologie, Universität Konstanz, Postfach 5560, D-7750, Konstanz, Germany

    Horst Sund  & Volker Ullrich  & 

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Schirmer, R.H., Schulz, G.E. (1983). Flavoproteins of Known Three-Dimensional Structure. In: Sund, H., Ullrich, V. (eds) Biological Oxidations. Colloquium der Gesellschaft für Biologische Chemie 14.–16. April 1983 in Mosbach/Baden, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69467-7_5

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  • DOI: https://doi.org/10.1007/978-3-642-69467-7_5

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