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Lysozyme (Muramidase) and Hemolytic Complement (CH50U) in Sera of Beagle Dogs and Minipigs After Longterm Application of Different Preparations of Estrogens and Gestagens

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Book cover Further Studies in the Assessment of Toxic Actions

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 4))

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Abstract

In studies for the chronic toxicity of estrogens and gestagens, lysozyme and hemolytic complement (CH50U) in sera of beagle dogs and minipigs were measured. Various doses of the sexsteroids were given: 0.01 mg, 0.1 mg and 1.0 mg/kg respectively. The influence of the steroids on the tested parameters after an application for 6 months was not significant, only in a single series with unphysiologically, high dosages of the preparations were some values changed significantly.

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References

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Author information

Authors and Affiliations

  1. Institute of Medical Microbiology of the University of Jena, GDR

    A. Stelzner

  2. Clinic for Obstetrics and Gynecology of the University of Jena, GDR

    G. Klinger

  3. Central Institute of Microbiology and Experimental Therapy of the Academy of Sciences of GDR in Jena, GDR

    M. Oettel, H. Hoffmann & H.-G. Hillesheim

  4. VEB Jenapharm Jena, GDR

    K.-H. Chemnitius

  5. Centre for animal experiments of the University of Jena, GDR

    E. Schimke & M. Zieger

Authors
  1. A. Stelzner
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  2. G. Klinger
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  3. M. Oettel
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  4. H. Hoffmann
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  5. H.-G. Hillesheim
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  6. K.-H. Chemnitius
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  7. E. Schimke
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  8. M. Zieger
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers

  2. Institut für Pharmakologie und Toxikologie, Friedrich-Schiller-Universität Jena, DDR-6900, Jena, GDR

    Wolfgang Klinger

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© 1980 Springer-Verlag

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Stelzner, A. et al. (1980). Lysozyme (Muramidase) and Hemolytic Complement (CH50U) in Sera of Beagle Dogs and Minipigs After Longterm Application of Different Preparations of Estrogens and Gestagens. In: Chambers, P.L., Klinger, W. (eds) Further Studies in the Assessment of Toxic Actions. Archives of Toxicology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67729-8_34

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  • DOI: https://doi.org/10.1007/978-3-642-67729-8_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10191-8

  • Online ISBN: 978-3-642-67729-8

  • eBook Packages: Springer Book Archive

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